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Apolipoprotein E phenotypes and plasma lipids in young and middle-aged subjects
- Source :
- The Tohoku journal of experimental medicine. 148(1)
- Publication Year :
- 1986
-
Abstract
- The relationship between apolipoprotein (apo) E phenotypes and the levels of plasma lipid, lipoprotein and apo E in young (mean, 21 years of age) and middle-aged (mean, 49 years of age) subjects was investigated. Apo E phenotypes were determined by a rapid flat gel isoelectric focusing method that we had developed previously. Young subjects with apo E3/2 and E4/3 had significantly higher levels of plasma triglyceride (TG), very low density lipoprotein (VLDL)-TG and VLDL-cholesterol than those with apo E3/3. Middle-aged subjects with apo E3/2 (54.5%) and E4/3 (39.1%) had higher frequency of hyperlipoproteinemia (mainly type IV) than those with apo E3/3 (25.8%). Furthermore, the middle-aged subjects with apo E3/2 had significantly higher levels of plasma TG, VLDL-TG and apo E, and significantly lower levels of plasma high density lipoprotein-cholesterol than those with apo E3/3. These results indicate that apo E phenotype E3/2 and E4/3 are associated with lipid abnormalities even in young subjects, which may be caused by impaired functions of apo E2 and E4.
- Subjects :
- Apolipoprotein E
Adult
Male
medicine.medical_specialty
Very low-density lipoprotein
Hyperlipoproteinemias
Apolipoprotein B
Adolescent
Lipoproteins
High density
General Biochemistry, Genetics and Molecular Biology
Apolipoproteins E
Internal medicine
Plasma lipids
medicine
Humans
Triglycerides
biology
Chemistry
Isoelectric focusing
Age Factors
General Medicine
Middle Aged
Phenotype
Lipids
Endocrinology
Cholesterol
biology.protein
lipids (amino acids, peptides, and proteins)
Female
Lipoprotein
Subjects
Details
- ISSN :
- 00408727
- Volume :
- 148
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The Tohoku journal of experimental medicine
- Accession number :
- edsair.doi.dedup.....b8459e23cc06d18b13353f4ad689dd5c