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Plasma polyphenols associated with lower high-sensitivity C-reactive protein concentrations:a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
- Source :
- Harms, L M, Scalbert, A, Zamora-Ros, R, Rinaldi, S, Jenab, M, Murphy, N, Achaintre, D, Tjønneland, A, Olsen, A, Overvad, K, Mancini, F R, Mahamat-Saleh, Y, Boutron-Ruault, M-C, Kühn, T, Katzke, V, Trichopoulou, A, Martimianaki, G, Karakatsani, A, Palli, D, Panico, S, Sieri, S, Tumino, R, Sacerdote, C, Bueno-de-Mesquita, B, Vermeulen, R C H, Weiderpass, E, Nøst, T H, Lasheras, C, Rodríguez-Barranco, M, Huerta, J M, Barricarte, A, Dorronsoro, M, Hultdin, J, Schmidt, J A, Gunter, M, Riboli, E & Aleksandrova, K 2020, ' Plasma polyphenols associated with lower high-sensitivity C-reactive protein concentrations : a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort ', The British Journal of Nutrition, vol. 123, no. 2, 0007114519002538, pp. 198-208 . https://doi.org/10.1017/S0007114519002538, Harms, L M, Scalbert, A, Zamora-Ros, R, Rinaldi, S, Jenab, M, Murphy, N, Achaintre, D, Tjønneland, A, Olsen, A, Overvad, K, Mancini, F R, Mahamat-Saleh, Y, Boutron-Ruault, M-C, Kuehn, T, Katzke, V, Trichopoulou, A, Martimianaki, G, Karakatsani, A, Palli, D, Panico, S, Sieri, S, Tumino, R, Sacerdote, C, Bueno-de-Mesquita, B, Vermeulen, R C H, Weiderpass, E, Nost, T H, Lasheras, C, Rodriguez-Barranco, M, Maria Huerta, J, Barricarte, A, Dorronsoro, M, Hultdin, J, Schmidt, J A, Gunter, M, Riboli, E & Aleksandrova, K 2020, ' Plasma polyphenols associated with lower high-sensitivity C-reactive protein concentrations : a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort ', British Journal of Nutrition, vol. 123, no. 2, pp. 198-208 . https://doi.org/10.1017/S0007114519002538, British Journal of Nutrition, British Journal of Nutrition, Cambridge University Press (CUP), 2020, 123 (2), pp.198-208. ⟨10.1017/S0007114519002538⟩, Dipòsit Digital de la UB, Universidad de Barcelona, British Journal of Nutrition, 123(2), 198. Cambridge University Press [etc.], Harms, L M, Scalbert, A, Zamora-Ros, R, Rinaldi, S, Jenab, M, Murphy, N, Achaintre, D, Tjønneland, A, Olsen, A, Overvad, K, Mancini, F R, Mahamat-Saleh, Y, Boutron-Ruault, M-C, Kühn, T, Katzke, V, Trichopoulou, A, Martimianaki, G, Karakatsani, A, Palli, D, Panico, S, Sieri, S, Tumino, R, Sacerdote, C, Bueno-de-Mesquita, B, Vermeulen, R C H, Weiderpass, E, Nøst, T H, Lasheras, C, Rodríguez-Barranco, M, Huerta, J M, Barricarte, A, Dorronsoro, M, Hultdin, J, Schmidt, J A, Gunter, M, Riboli, E & Aleksandrova, K 2020, ' Plasma polyphenols associated with lower high-sensitivity C-reactive protein concentrations : a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort ', The British Journal of Nutrition, vol. 123, no. 2, pp. 198-208 . https://doi.org/10.1017/S0007114519002538, The British Journal of Nutrition
- Publication Year :
- 2020
-
Abstract
- Experimental studies have reported on the anti-inflammatory properties of polyphenols. However, results from epidemiological investigations have been inconsistent and especially studies using biomarkers for assessment of polyphenol intake have been scant. We aimed to characterise the association between plasma concentrations of thirty-five polyphenol compounds and low-grade systemic inflammation state as measured by high-sensitivity C-reactive protein (hsCRP). A cross-sectional data analysis was performed based on 315 participants in the European Prospective Investigation into Cancer and Nutrition cohort with available measurements of plasma polyphenols and hsCRP. In logistic regression analysis, the OR and 95 % CI of elevated serum hsCRP (>3 mg/l) were calculated within quartiles and per standard deviation higher level of plasma polyphenol concentrations. In a multivariable-adjusted model, the sum of plasma concentrations of all polyphenols measured (per standard deviation) was associated with 29 (95 % CI 50, 1) % lower odds of elevated hsCRP. In the class of flavonoids, daidzein was inversely associated with elevated hsCRP (OR 0 center dot 66, 95 % CI 0 center dot 46, 0 center dot 96). Among phenolic acids, statistically significant associations were observed for 3,5-dihydroxyphenylpropionic acid (OR 0 center dot 58, 95 % CI 0 center dot 39, 0 center dot 86), 3,4-dihydroxyphenylpropionic acid (OR 0 center dot 63, 95 % CI 0 center dot 46, 0 center dot 87), ferulic acid (OR 0 center dot 65, 95 % CI 0 center dot 44, 0 center dot 96) and caffeic acid (OR 0 center dot 69, 95 % CI 0 center dot 51, 0 center dot 93). The odds of elevated hsCRP were significantly reduced for hydroxytyrosol (OR 0 center dot 67, 95 % CI 0 center dot 48, 0 center dot 93). The present study showed that polyphenol biomarkers are associated with lower odds of elevated hsCRP. Whether diet rich in bioactive polyphenol compounds could be an effective strategy to prevent or modulate deleterious health effects of inflammation should be addressed by further well-powered longitudinal studies.
- Subjects :
- Male
0301 basic medicine
Medicine (miscellaneous)
Gastroenterology
Cohort Studies
chronic diseases
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
Neoplasms
Caffeic acid
Medicine
Malalties cròniques
odds ratio
Prospective Studies
Prospective cohort study
Nutrition and Dietetics
VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801
biology
food and beverages
Full Papers
Middle Aged
3. Good health
European Prospective Investigation into Cancer and Nutrition
Näringslära
Europe
hormone replacement therapy
Polifenols
Cohort
Female
standard deviation
Human and Clinical Nutrition
Cohort study
Adult
Plasma measurements
medicine.medical_specialty
030209 endocrinology & metabolism
body mass index
Diet Surveys
C-reactive protein
03 medical and health sciences
Internal medicine
Humans
polyphenols
Aged
Inflammation
030109 nutrition & dietetics
business.industry
Daidzein
Polyphenols
Diet
cardiovascular diseases
Cross-Sectional Studies
Nutrition Assessment
chemistry
confidence interval
Polyphenol
plasma measurements
inflammation
Chronic diseases
randomized controlled trial
biology.protein
high-sensitivity C-reactive protein
VDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801
business
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 00071145 and 14752662
- Database :
- OpenAIRE
- Journal :
- Harms, L M, Scalbert, A, Zamora-Ros, R, Rinaldi, S, Jenab, M, Murphy, N, Achaintre, D, Tjønneland, A, Olsen, A, Overvad, K, Mancini, F R, Mahamat-Saleh, Y, Boutron-Ruault, M-C, Kühn, T, Katzke, V, Trichopoulou, A, Martimianaki, G, Karakatsani, A, Palli, D, Panico, S, Sieri, S, Tumino, R, Sacerdote, C, Bueno-de-Mesquita, B, Vermeulen, R C H, Weiderpass, E, Nøst, T H, Lasheras, C, Rodríguez-Barranco, M, Huerta, J M, Barricarte, A, Dorronsoro, M, Hultdin, J, Schmidt, J A, Gunter, M, Riboli, E & Aleksandrova, K 2020, ' Plasma polyphenols associated with lower high-sensitivity C-reactive protein concentrations : a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort ', The British Journal of Nutrition, vol. 123, no. 2, 0007114519002538, pp. 198-208 . https://doi.org/10.1017/S0007114519002538, Harms, L M, Scalbert, A, Zamora-Ros, R, Rinaldi, S, Jenab, M, Murphy, N, Achaintre, D, Tjønneland, A, Olsen, A, Overvad, K, Mancini, F R, Mahamat-Saleh, Y, Boutron-Ruault, M-C, Kuehn, T, Katzke, V, Trichopoulou, A, Martimianaki, G, Karakatsani, A, Palli, D, Panico, S, Sieri, S, Tumino, R, Sacerdote, C, Bueno-de-Mesquita, B, Vermeulen, R C H, Weiderpass, E, Nost, T H, Lasheras, C, Rodriguez-Barranco, M, Maria Huerta, J, Barricarte, A, Dorronsoro, M, Hultdin, J, Schmidt, J A, Gunter, M, Riboli, E & Aleksandrova, K 2020, ' Plasma polyphenols associated with lower high-sensitivity C-reactive protein concentrations : a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort ', British Journal of Nutrition, vol. 123, no. 2, pp. 198-208 . https://doi.org/10.1017/S0007114519002538, British Journal of Nutrition, British Journal of Nutrition, Cambridge University Press (CUP), 2020, 123 (2), pp.198-208. ⟨10.1017/S0007114519002538⟩, Dipòsit Digital de la UB, Universidad de Barcelona, British Journal of Nutrition, 123(2), 198. Cambridge University Press [etc.], Harms, L M, Scalbert, A, Zamora-Ros, R, Rinaldi, S, Jenab, M, Murphy, N, Achaintre, D, Tjønneland, A, Olsen, A, Overvad, K, Mancini, F R, Mahamat-Saleh, Y, Boutron-Ruault, M-C, Kühn, T, Katzke, V, Trichopoulou, A, Martimianaki, G, Karakatsani, A, Palli, D, Panico, S, Sieri, S, Tumino, R, Sacerdote, C, Bueno-de-Mesquita, B, Vermeulen, R C H, Weiderpass, E, Nøst, T H, Lasheras, C, Rodríguez-Barranco, M, Huerta, J M, Barricarte, A, Dorronsoro, M, Hultdin, J, Schmidt, J A, Gunter, M, Riboli, E & Aleksandrova, K 2020, ' Plasma polyphenols associated with lower high-sensitivity C-reactive protein concentrations : a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort ', The British Journal of Nutrition, vol. 123, no. 2, pp. 198-208 . https://doi.org/10.1017/S0007114519002538, The British Journal of Nutrition
- Accession number :
- edsair.doi.dedup.....b852ab870bf7fc57ad39d0fb2635a981