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Medications adherence post-primary percutaneous coronary intervention in acute myocardial infarction: A population-based cohort study
- Source :
- Journal of clinical pharmacy and therapeuticsREFERENCES. 46(3)
- Publication Year :
- 2020
-
Abstract
- WHAT IS KNOWN AND OBJECTIVE The use of medications for secondary prevention is the cornerstone in the treatment of coronary artery disease (CAD). However, adherence to these medications is still suboptimal worldwide. This retrospective observational study aimed to assess the adherence to post-percutaneous coronary intervention (PCI) medications, along with predictors of non-adherence. METHODS We conducted a retrospective observational cohort study to assess the adherence to post-PCI medications by determining the rate of prescription refills for 12 months after discharge among STEMI patients, as well as predictors of non-adherence. Adherence was assessed by medication availability 80% of the time monitored by the prescription refills rate for 1 year post-discharge. RESULTS AND DISCUSSION A total of 1334 patients who presented with STEMI and underwent primary PCI were included in our retrospective analysis. The majority of patients included were male (96%) with a mean age of 51 ± 10.2 years. The overall adherence rate for all medications was only 28.4%, with an individual adherence rate of 50.5% for aspirin, 49.9% for P2 Y12 inhibitors, 48.1% for statins, 39.6% for beta-blockers and 42.9% for angiotensin-converting enzyme (ACE) inhibitors/angiotensin II receptor blockers (ARB). Factors that increased the likelihood of non-adherence were prolonged hospital length of stay and getting the medications with charge (aOR = 1.94, 95% CI 1.1-3.3; p-value = 0.017, aOR = 1.87, 95% CI 1.1-3.3; p-value = 0.029, respectively), while having a regular follow-up after discharge and attending the first clinic appointment were significantly associated with decreased likelihood of non-adherence (aOR = 0.01, 95% CI 0.004-0.04; p-value
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Comorbidity
030226 pharmacology & pharmacy
Medication Adherence
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Percutaneous Coronary Intervention
Sex Factors
Risk Factors
Internal medicine
Secondary Prevention
Medicine
Outpatient clinic
Humans
Pharmacology (medical)
030212 general & internal medicine
Myocardial infarction
Qatar
Aged
Retrospective Studies
Pharmacology
Aspirin
business.industry
Age Factors
Percutaneous coronary intervention
Retrospective cohort study
Cardiovascular Agents
Middle Aged
medicine.disease
Conventional PCI
Female
business
Cohort study
medicine.drug
Subjects
Details
- ISSN :
- 13652710
- Volume :
- 46
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of clinical pharmacy and therapeuticsREFERENCES
- Accession number :
- edsair.doi.dedup.....b868632a36b8f3646801800718e44af9