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mTOR Pathway Mutations and Response to Rapalogs in RCC-Letter
- Source :
- Clinical cancer research : an official journal of the American Association for Cancer Research. 23(17)
- Publication Year :
- 2017
-
Abstract
- We have read with interest the article by Kwiatkowski and colleagues ([1][1]) reporting mTOR pathway activating mutations as possible predictors of mTOR inhibitor response in renal cell carcinoma (RCC). Recent evidence indicate inferior global efficacy of rapalogs compared with new agents; however
- Subjects :
- 0301 basic medicine
Cancer Research
business.industry
TOR Serine-Threonine Kinases
urologic and male genital diseases
medicine.disease
Bioinformatics
Discovery and development of mTOR inhibitors
Kidney Neoplasms
Article
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Oncology
Renal cell carcinoma
030220 oncology & carcinogenesis
Mutation
Cancer research
Medicine
Humans
business
Carcinoma, Renal Cell
PI3K/AKT/mTOR pathway
Subjects
Details
- ISSN :
- 15573265
- Volume :
- 23
- Issue :
- 17
- Database :
- OpenAIRE
- Journal :
- Clinical cancer research : an official journal of the American Association for Cancer Research
- Accession number :
- edsair.doi.dedup.....b86e98a1ca41b3b0c7bf7cbac76239c6