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Chronic administration of cholinergic agents: effects on behavior and calmodulin
Chronic administration of cholinergic agents: effects on behavior and calmodulin
- Source :
- Pharmacology, biochemistry, and behavior. 18(4)
- Publication Year :
- 1983
-
Abstract
- Rats were implanted subcutaneously with Alza® pumps and 0.9% saline, physostigmine, or scopolamine were continuously infused for 15 days. Twenty-four hours after removal of the pumps all animals were trained on a single trail passive avoidance task. Twenty-four hours after training they were tested for retention. Following behavioral testing, animals were sacrificed, brain regions dissected, frozen and stored (−20°C) for calmodulin determinations. Animals which had previously received chronic infusions of scopolamine performed significantly better than controls, while those which previously received chronic infusions of physostigmine performed significantly worse during the retention test. No significant differences in calmodulin levels (soluble or particulate) were detected across brain regions or drug groups. These results indicate that continuous chronic infusion of drugs which can facilitate or inhibit CNS cholinergic activity can induce performance changes on a learning task opposite to those resulting following the acute administration of these same drugs.
- Subjects :
- Drug
Physostigmine
medicine.medical_specialty
Calmodulin
media_common.quotation_subject
medicine.medical_treatment
Clinical Biochemistry
Scopolamine
Behavioral testing
Pharmacology
Toxicology
Biochemistry
Hippocampus
Behavioral Neuroscience
Internal medicine
medicine
Avoidance Learning
Animals
Saline
Biological Psychiatry
media_common
Cerebral Cortex
biology
Behavior, Animal
business.industry
Calcium-Binding Proteins
Corpus Striatum
Rats, Inbred F344
Rats
Endocrinology
Parasympathomimetics
biology.protein
Cholinergic
Female
Passive avoidance
business
medicine.drug
Subjects
Details
- ISSN :
- 00913057
- Volume :
- 18
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Pharmacology, biochemistry, and behavior
- Accession number :
- edsair.doi.dedup.....b8890739f4addd8356beccb54293d539