Back to Search
Start Over
Quantitative Kinetics Evaluation of Blocks Versus Granules of Biphasic Calcium Phosphate Scaffolds (HA/β-TCP 30/70) by Synchrotron Radiation X-ray Microtomography: A Human Study
Quantitative Kinetics Evaluation of Blocks Versus Granules of Biphasic Calcium Phosphate Scaffolds (HA/β-TCP 30/70) by Synchrotron Radiation X-ray Microtomography: A Human Study
- Source :
- Implant dentistry. 25(1)
- Publication Year :
- 2015
-
Abstract
- Introduction Successful bone regeneration using both granules and blocks of biphasic calcium phosphate materials has been reported in the recent literature, in some clinical applications for maxillary sinus elevation, but the long-term kinetics of bone regeneration has still not been fully investigated. Materials and methods Twenty-four bilateral sinus augmentation procedures were performed and grafted with hydroxyapatite/β-tricalcium phosphate 30/70, 12 with granules and 12 with blocks. The samples were retrieved at different time points and were evaluated for bone regeneration, graft resorption, neovascularization, and morphometric parameters by computed microtomography and histology. Results A large amount of newly formed bone was detected in the retrieved specimens, together with a good rate of biomaterial resorption and the formation of a homogeneous and rich net of new vessels. The morphometric values were comparable at 5/6 months from grafting but, 9 months after grafting, revealed that the block-based specimens mimicked slightly better than granule-based samples the healthy native bone of the maxillary site. Conclusion The scaffold morphology was confirmed to influence the long-term kinetics of bone regeneration.
- Subjects :
- 0301 basic medicine
Male
Pathology
medicine.medical_specialty
Materials science
X-ray microtomography
Bone Regeneration
Maxillary sinus
Sinus Floor Augmentation
Neovascularization
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
medicine
Humans
Bone regeneration
Aged
Tissue Scaffolds
Granule (cell biology)
Biomaterial
030206 dentistry
X-Ray Microtomography
Middle Aged
Phosphate
Resorption
Kinetics
Microscopy, Electron
030104 developmental biology
medicine.anatomical_structure
chemistry
Female
Hydroxyapatites
Oral Surgery
medicine.symptom
Biomedical engineering
Subjects
Details
- ISSN :
- 15382982
- Volume :
- 25
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Implant dentistry
- Accession number :
- edsair.doi.dedup.....b88fe283eba1faedc29301926dca19db