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Increased serum cathepsin S in patients with atherosclerosis and diabetes
- Source :
- Atherosclerosis. 186:411-419
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- Atherosclerosis and diabetes are closely associated and both involve extensive degradation of the aortic elastin. Increased elastase activity has been detected in diabetic animal aortae. We have demonstrated enhanced elastolytic cathepsin S in human atherosclerotic lesions but insufficient amounts of its endogenous inhibitor cystatin C, suggesting alterations of serum cathepsin S and/or cystatin C in patients with atherosclerosis or diabetes. In this study, we measured levels of both cathepsin S and cystatin C in sera from 240 patients by ELISA. Among these patients, 107 had a diagnosis of atherosclerotic stenosis, 103 were diabetic, and 30 had neither condition. Multiple linear regression analysis demonstrated that significantly higher serum levels of cathepsin S in patients with either atherosclerotic stenosis (p
- Subjects :
- Male
medicine.medical_specialty
Population
Renal function
Cathepsin C
chemistry.chemical_compound
Diabetes mellitus
Internal medicine
Diabetes Mellitus
medicine
Humans
Cystatin C
education
Aged
Cathepsin S
Creatinine
education.field_of_study
biology
business.industry
Middle Aged
Atherosclerosis
medicine.disease
Cathepsins
Cystatins
Endocrinology
chemistry
biology.protein
Female
Cystatin
Cardiology and Cardiovascular Medicine
business
Biomarkers
Subjects
Details
- ISSN :
- 00219150
- Volume :
- 186
- Database :
- OpenAIRE
- Journal :
- Atherosclerosis
- Accession number :
- edsair.doi.dedup.....b8ba036a18257768bdf7b62fd3f1e669