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Hippocampal Atrophy Varies by Neuropsychologically Defined MCI Among Men in Their 50s
Hippocampal Atrophy Varies by Neuropsychologically Defined MCI Among Men in Their 50s
- Source :
- The American Journal of Geriatric Psychiatry. 23:456-465
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Objective In an effort to address earliest detection of mild cognitive impairment (MCI), we examined hippocampal volumes and atrophy in middle-aged men to explore neuroanatomical support for different neuropsychological definitions of MCI. Methods 460 men aged 51–60 years underwent neuropsychological testing and MRI. MCI was defined according to five criteria sets. MRI-derived hippocampal volume and hippocampal occupancy (HOC) were obtained via FreeSurfer. Statistical analyses were performed using linear mixed models. Results Differences in HOC between normal cognitive functioning, amnestic, and non-amnestic MCI were observed using MCI criteria that required one impaired (>1.5 SD) cognitive measure in a given cognitive domain or a cognitive composite score method with a cut-point 2 SD below the mean. Differences in standard hippocampal volume were only found between normal and amnestic presentations and only when using the composite score method. Conclusion Results provide empirical support for detection of pre-MCI in younger cohorts. Convergence of neuropsychological and neuroanatomical data, particularly HOC (as opposed to standard cross-sectional volume), supports early identification of MCI as defined by some neuropsychological criteria.
- Subjects :
- Male
medicine.medical_specialty
Neuropsychological Tests
Audiology
Hippocampal formation
Hippocampus
Article
Developmental psychology
Atrophy
medicine
Humans
Cognitive Dysfunction
Mental Competency
Longitudinal Studies
Cognitive skill
Intelligence Tests
medicine.diagnostic_test
Intelligence quotient
Neuropsychology
Magnetic resonance imaging
Cognition
Organ Size
Middle Aged
medicine.disease
Magnetic Resonance Imaging
United States
Hippocampal atrophy
Psychiatry and Mental health
Early Diagnosis
Disease Progression
Linear Models
Geriatrics and Gerontology
Psychology
Subjects
Details
- ISSN :
- 10647481
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- The American Journal of Geriatric Psychiatry
- Accession number :
- edsair.doi.dedup.....b8cced4c712bacec1bca695a5e4b7457
- Full Text :
- https://doi.org/10.1016/j.jagp.2014.08.011