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Hippocampal Atrophy Varies by Neuropsychologically Defined MCI Among Men in Their 50s

Hippocampal Atrophy Varies by Neuropsychologically Defined MCI Among Men in Their 50s

Authors :
Ming T. Tsuang
William S. Kremen
Michael J. Lyons
Anders M. Dale
Christine Fennema-Notestine
Michael C. Neale
Lisa T. Eyler
Wesley K. Thompson
Kristen C. Jacobson
Matthew S. Panizzon
Rosemary Toomey
Kelly M. Spoon
Carol E. Franz
Eero Vuoksimaa
Hong Xian
Amy J. Jak
Source :
The American Journal of Geriatric Psychiatry. 23:456-465
Publication Year :
2015
Publisher :
Elsevier BV, 2015.

Abstract

Objective In an effort to address earliest detection of mild cognitive impairment (MCI), we examined hippocampal volumes and atrophy in middle-aged men to explore neuroanatomical support for different neuropsychological definitions of MCI. Methods 460 men aged 51–60 years underwent neuropsychological testing and MRI. MCI was defined according to five criteria sets. MRI-derived hippocampal volume and hippocampal occupancy (HOC) were obtained via FreeSurfer. Statistical analyses were performed using linear mixed models. Results Differences in HOC between normal cognitive functioning, amnestic, and non-amnestic MCI were observed using MCI criteria that required one impaired (>1.5 SD) cognitive measure in a given cognitive domain or a cognitive composite score method with a cut-point 2 SD below the mean. Differences in standard hippocampal volume were only found between normal and amnestic presentations and only when using the composite score method. Conclusion Results provide empirical support for detection of pre-MCI in younger cohorts. Convergence of neuropsychological and neuroanatomical data, particularly HOC (as opposed to standard cross-sectional volume), supports early identification of MCI as defined by some neuropsychological criteria.

Details

ISSN :
10647481
Volume :
23
Database :
OpenAIRE
Journal :
The American Journal of Geriatric Psychiatry
Accession number :
edsair.doi.dedup.....b8cced4c712bacec1bca695a5e4b7457
Full Text :
https://doi.org/10.1016/j.jagp.2014.08.011