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Rheumatoid arthritis response to treatment across IgG1 allotype - anti-TNF incompatibility: a case-only study
Rheumatoid arthritis response to treatment across IgG1 allotype - anti-TNF incompatibility: a case-only study
- Source :
- ARTHRITIS RESEARCH & THERAPY, r-FISABIO: Repositorio Institucional de Producción Científica, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Recercat. Dipósit de la Recerca de Catalunya, instname, RUNA. Repositorio da Consellería de Sanidade e Sergas, Servizo Galego de Saúde (SERGAS), RUC. Repositorio da Universidade da Coruña, Dipòsit Digital de la UB, Universidad de Barcelona, Arthritis Research & Therapy, r-FISABIO. Repositorio Institucional de Producción Científica, Arthritis Research and Therapy, 17, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, Digital.CSIC. Repositorio Institucional del CSIC, Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid, Consejería de Sanidad de la Comunidad de Madrid, Biblos-e Archivo. Repositorio Institucional de la UAM
- Publication Year :
- 2015
- Publisher :
- BIOMED CENTRAL LTD, 2015.
-
Abstract
- Montes, Ariana et al.<br />[Introduction] We have hypothesized that incompatibility between the G1m genotype of the patient and the G1m1 and G1m17 allotypes carried by infliximab (INX) and adalimumab (ADM) could decrease the efficacy of these anti-tumor necrosis factor (anti-TNF) antibodies in the treatment of rheumatoid arthritis (RA).<br />[Methods] The G1m genotypes were analyzed in three collections of patients with RA totaling 1037 subjects. The first, used for discovery, comprised 215 Spanish patients. The second and third were successively used for replication. They included 429 British and Greek patients and 393 Spanish and British patients, respectively. Two outcomes were considered: change in the Disease Activity Score in 28 joint (ΔDAS28) and the European League Against Rheumatism (EULAR) response criteria.<br />[Results] An association between less response to INX and incompatibility of the G1m1,17 allotype was found in the discovery collection at 6 months of treatment (P = 0.03). This association was confirmed in the replications (P = 0.02 and 0.08, respectively) leading to a global association (P = 0.001) that involved a mean difference in ΔDAS28 of 0.4 units between compatible and incompatible patients (2.3 ± 1.5 in compatible patients vs. 1.9 ± 1.5 in incompatible patients) and an increase in responders and decrease in non-responders according to the EULAR criteria (P = 0.03). A similar association was suggested for patients treated with ADM in the discovery collection, but it was not supported by replication.<br />[Conclusions] Our results suggest that G1m1,17 allotypes are associated with response to INX and could aid improved therapeutic targeting in RA.<br />Funding was provided by grants PI11/01048, PI12/01909 and by RETICS Program, RD08/0075/0019 and RD12/0009/0008 (RIER) of the Instituto de Salud Carlos III (Spain) that are partially financed by the European Regional Development Fund of the European Union.
- Subjects :
- Male
Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Tumor Necrosis Factors [Medical Subject Headings]
Immunoglobulin G
Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]
Arthritis, Rheumatoid
Immunology and Allergy
Single nucleotide
skin and connective tissue diseases
biology
IgG1 allotype
Drugs
Enfermedades reumáticas
Middle Aged
Allotype
Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Monokines::Tumor Necrosis Factor-alpha [Medical Subject Headings]
Articulaciones
Treatment Outcome
Estudi de casos
Rheumatoid arthritis
Diseases::Musculoskeletal Diseases::Rheumatic Diseases [Medical Subject Headings]
Arthritis rheumatoid
Antirheumatic Agents
Teràpia genètica
Tumor necrosis factor alpha
Female
Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings]
Antibody
Medicaments
medicine.drug
Research Article
Adult
musculoskeletal diseases
medicine.medical_specialty
Genotype
Medicina
Anatomy::Musculoskeletal System::Skeleton::Joints [Medical Subject Headings]
Immunology
Molecular Sequence Data
Artritis reumatoide
Polymorphism, Single Nucleotide
Gene therapy
Rheumatology
Internal medicine
Diseases::Musculoskeletal Diseases::Joint Diseases::Arthritis::Arthritis, Rheumatoid [Medical Subject Headings]
medicine
Adalimumab
Humans
Polymorphism
Immunoglobulin Allotypes
Base Sequence
business.industry
Tumor Necrosis Factor-alpha
medicine.disease
Infliximab
Factor de necrosis tumoral alfa
Treatment
biology.protein
Case studies
business
Genotipo
Subjects
Details
- ISSN :
- 14786354
- Database :
- OpenAIRE
- Journal :
- ARTHRITIS RESEARCH & THERAPY, r-FISABIO: Repositorio Institucional de Producción Científica, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Recercat. Dipósit de la Recerca de Catalunya, instname, RUNA. Repositorio da Consellería de Sanidade e Sergas, Servizo Galego de Saúde (SERGAS), RUC. Repositorio da Universidade da Coruña, Dipòsit Digital de la UB, Universidad de Barcelona, Arthritis Research & Therapy, r-FISABIO. Repositorio Institucional de Producción Científica, Arthritis Research and Therapy, 17, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, Digital.CSIC. Repositorio Institucional del CSIC, Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid, Consejería de Sanidad de la Comunidad de Madrid, Biblos-e Archivo. Repositorio Institucional de la UAM
- Accession number :
- edsair.doi.dedup.....b8dc3e17b6b85c173efb70c7e050190b