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Rheumatoid arthritis response to treatment across IgG1 allotype - anti-TNF incompatibility: a case-only study

Rheumatoid arthritis response to treatment across IgG1 allotype - anti-TNF incompatibility: a case-only study

Authors :
Miguel Ferrer
Ann W. Morgan
Beatriz Joven
John D. Isaacs
Theologia Sarafidou
Enrique Raya
Rafael Cáliz
Javier Narváez
Ariana Montes
Ana Márquez
C. Magro
Javier Martín
F. Navarro-Sarabia
Moreira Vf
María del Carmen Ordóñez
Lara Valor
Alejandro Balsa
Antonio Fernández-Nebro
Juan José Alegre-Sancho
Arturo Rodríguez de la Serna
Anne Barton
Rosa Garcia-Portales
Manuel J. Moreno-Ramos
Antonio Gonzalez
Anthony G. Wilson
Francisco J. Blanco
Patricia Carreira
Yiannis Vasilopoulos
Juan J. Gomez-Reino
Darren Plant
Berta Magallares
Juan D. Cañete
Eva Perez-Pampin
Dora Pascual-Salcedo
Universitat de Barcelona
Instituto de Salud Carlos III
European Commission
[Montes,A
Perez-Pampin,E] Laboratorio de Investigacion 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria - Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain. [Navarro-Sarabia, F
Moreira,V] Rheumatology Unit, Hospital Universitario Virgen Macarena, Sevilla, Spain. [Rodríguez de la Serna,A
Magallares,B] Rheumatology Unit, Hospital Santa Creu e San Pau, Barcelona, Spain. [Vasilopoulos,Y
Sarafidou,T] Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece. [Fernández-Nebro,A
Ordóñez,MC] Servicio de Reumatología, HRU Carlos Haya, Universidad de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain. [Narváez,J] Department of Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain. [Cañete,Jd] Rheumatology Unit, Hospital Clinic, Barcelona, Spain. [Marquez,A] Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Granada, Spain. [Pascual-Salcedo,D] Department of Immunology, Instituto de Investigación Hospital Universitario La Paz, Hospital La Paz, Madrid, Spain. [Joven,B
Carreira,P] Department of Rheumatology, Hospital 12 de Octubre, Madrid, Spain. [Moreno-Ramos,MJ] Department of Rheumatology, Hospital Virgen de la Arrixaca, Murcia, Spain. [Caliz,R
Ferrer,NA] Rheumatology Unit, Hospital Universitario Virgen de las Nieves, Granada, Spain. [Garcia-Portales,R] Department of Rheumatology, Hospital Virgen de la Victoria, Málaga, Spain. [Blanco,FJ] Rheumatology Department, Instituto de Investigacion Biomedica-Complejo Hospitalario Universitario A Coruna
Department of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain. [Magro,C
Raya,E] Department of Rheumatology, Hospital Clínico San Cecilio, Granada, Spain. [Valor,L] Rheumatology Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain. [Alegre-Sancho,JJ] Department of Rheumatology, Hospital Doctor Peset, Valencia, Spain. [Balsa,A] Department of Rheumatology, Instituto de Investigación Hospital Universitario La Paz, Hospital Universitario La Paz, Madrid, Spain.[Martin,J] Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Granada, Spain. [Plant,D] NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. [Isaacs,J] Musculoskeletal Research Group, Institute of Cellular Medicine, The Medical School, Newcastle University
National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle upon Tyne, Newcastle, UK. [Morgan,AW] Leeds Institute of Rheumatic and Musculoskeletal Medicine, St. James's University Hospital, University of Leeds
NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, UK. [Barton,A] NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre
Arthritis Research UK-Centre for Genetics and Genomics, The University of Manchester, Manchester, UK. [Wilson,AG] University College Dublin, Dublin, Ireland. [Gómez-Reino,JJ] Laboratorio de Investigacion 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria - Hospital Clinico Universitario de Santiago
Department of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain. [Gonzalez,A] Laboratorio de Investigacion 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria - Hospital Clinico Universitario de Santiago
Laboratorio Investigacion 10, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain.
Funding was provided by grants PI11/01048, PI12/01909 and by RETICS Program, RD08/0075/0019 and RD12/0009/0008 (RIER) of the Instituto de Salud Carlos III (Spain) that are partially financed by the European Regional Development Fund of the European Union
UAM. Departamento de Medicina
Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)
Source :
ARTHRITIS RESEARCH & THERAPY, r-FISABIO: Repositorio Institucional de Producción Científica, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Recercat. Dipósit de la Recerca de Catalunya, instname, RUNA. Repositorio da Consellería de Sanidade e Sergas, Servizo Galego de Saúde (SERGAS), RUC. Repositorio da Universidade da Coruña, Dipòsit Digital de la UB, Universidad de Barcelona, Arthritis Research & Therapy, r-FISABIO. Repositorio Institucional de Producción Científica, Arthritis Research and Therapy, 17, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, Digital.CSIC. Repositorio Institucional del CSIC, Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid, Consejería de Sanidad de la Comunidad de Madrid, Biblos-e Archivo. Repositorio Institucional de la UAM
Publication Year :
2015
Publisher :
BIOMED CENTRAL LTD, 2015.

Abstract

Montes, Ariana et al.<br />[Introduction] We have hypothesized that incompatibility between the G1m genotype of the patient and the G1m1 and G1m17 allotypes carried by infliximab (INX) and adalimumab (ADM) could decrease the efficacy of these anti-tumor necrosis factor (anti-TNF) antibodies in the treatment of rheumatoid arthritis (RA).<br />[Methods] The G1m genotypes were analyzed in three collections of patients with RA totaling 1037 subjects. The first, used for discovery, comprised 215 Spanish patients. The second and third were successively used for replication. They included 429 British and Greek patients and 393 Spanish and British patients, respectively. Two outcomes were considered: change in the Disease Activity Score in 28 joint (ΔDAS28) and the European League Against Rheumatism (EULAR) response criteria.<br />[Results] An association between less response to INX and incompatibility of the G1m1,17 allotype was found in the discovery collection at 6 months of treatment (P = 0.03). This association was confirmed in the replications (P = 0.02 and 0.08, respectively) leading to a global association (P = 0.001) that involved a mean difference in ΔDAS28 of 0.4 units between compatible and incompatible patients (2.3 ± 1.5 in compatible patients vs. 1.9 ± 1.5 in incompatible patients) and an increase in responders and decrease in non-responders according to the EULAR criteria (P = 0.03). A similar association was suggested for patients treated with ADM in the discovery collection, but it was not supported by replication.<br />[Conclusions] Our results suggest that G1m1,17 allotypes are associated with response to INX and could aid improved therapeutic targeting in RA.<br />Funding was provided by grants PI11/01048, PI12/01909 and by RETICS Program, RD08/0075/0019 and RD12/0009/0008 (RIER) of the Instituto de Salud Carlos III (Spain) that are partially financed by the European Regional Development Fund of the European Union.

Subjects

Subjects :
Male
Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Tumor Necrosis Factors [Medical Subject Headings]
Immunoglobulin G
Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]
Arthritis, Rheumatoid
Immunology and Allergy
Single nucleotide
skin and connective tissue diseases
biology
IgG1 allotype
Drugs
Enfermedades reumáticas
Middle Aged
Allotype
Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Monokines::Tumor Necrosis Factor-alpha [Medical Subject Headings]
Articulaciones
Treatment Outcome
Estudi de casos
Rheumatoid arthritis
Diseases::Musculoskeletal Diseases::Rheumatic Diseases [Medical Subject Headings]
Arthritis rheumatoid
Antirheumatic Agents
Teràpia genètica
Tumor necrosis factor alpha
Female
Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings]
Antibody
Medicaments
medicine.drug
Research Article
Adult
musculoskeletal diseases
medicine.medical_specialty
Genotype
Medicina
Anatomy::Musculoskeletal System::Skeleton::Joints [Medical Subject Headings]
Immunology
Molecular Sequence Data
Artritis reumatoide
Polymorphism, Single Nucleotide
Gene therapy
Rheumatology
Internal medicine
Diseases::Musculoskeletal Diseases::Joint Diseases::Arthritis::Arthritis, Rheumatoid [Medical Subject Headings]
medicine
Adalimumab
Humans
Polymorphism
Immunoglobulin Allotypes
Base Sequence
business.industry
Tumor Necrosis Factor-alpha
medicine.disease
Infliximab
Factor de necrosis tumoral alfa
Treatment
biology.protein
Case studies
business
Genotipo

Details

ISSN :
14786354
Database :
OpenAIRE
Journal :
ARTHRITIS RESEARCH & THERAPY, r-FISABIO: Repositorio Institucional de Producción Científica, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Recercat. Dipósit de la Recerca de Catalunya, instname, RUNA. Repositorio da Consellería de Sanidade e Sergas, Servizo Galego de Saúde (SERGAS), RUC. Repositorio da Universidade da Coruña, Dipòsit Digital de la UB, Universidad de Barcelona, Arthritis Research & Therapy, r-FISABIO. Repositorio Institucional de Producción Científica, Arthritis Research and Therapy, 17, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, Digital.CSIC. Repositorio Institucional del CSIC, Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid, Consejería de Sanidad de la Comunidad de Madrid, Biblos-e Archivo. Repositorio Institucional de la UAM
Accession number :
edsair.doi.dedup.....b8dc3e17b6b85c173efb70c7e050190b