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One year follow-up after a randomized controlled trial of a 130 g/day low-carbohydrate diet in patients with type 2 diabetes mellitus and poor glycemic control
One year follow-up after a randomized controlled trial of a 130 g/day low-carbohydrate diet in patients with type 2 diabetes mellitus and poor glycemic control
- Source :
- PLoS ONE, Vol 12, Iss 12, p e0188892 (2017), PLoS ONE
- Publication Year :
- 2017
- Publisher :
- Public Library of Science (PLoS), 2017.
-
Abstract
- Background & aims Recently, we conducted a prospective randomized controlled trial (RCT) showing that a 6-month 130g/day low-carbohydrate diet (LCD) reduced HbA1c and BMI more than a calorie restricted diet (CRD). [1] To assess whether the benefits of the LCD persisted after the intensive intervention, we compared HbA1c and BMI between the LCD and CRD groups at 1 year after the end of the 6-month RCT. Methods Following the end of the 6-month RCT, patients were allowed to manage their own diets with periodic outpatient visits. One year later, we analyzed clinical and nutrition data. Results Of the 66 participants in the original study, 27 in the CRD group and 22 in the LCD group completed this trial. One year after the end of the original RCT, the carbohydrate intake was comparable between the groups (215 [189–243]/day in the CRD group and 214 (176–262) g/day in the LCD group). Compared with the baseline data, HbA1c and BMI were decreased in both groups (CRD: HbA1c -0.4 [-0.9 to 0.3] % and BMI -0.63 [-1.20 to 0.18] kg/m2; LCD: HbA1c -0.35 [-1.0 to 0.35] % and BMI -0.77 [-1.15 to -0.12] kg/m2). There were no significant differences in HbA1c and BMI between the groups. Conclusions One year after the diet therapy intervention, the beneficial effect of the LCD on reduction of HbA1c and BMI did not persist in comparison with CRD. However, combining the data of both groups, significant improvements in HbA1c and BMI from baseline were observed. Although the superiority of the LCD disappeared 1 year after the intensive intervention, these data suggest that well-constructed nutrition therapy programs, both CRD and LCD, were equally effective in improving HbA1c for at least 1 year. Trial registration University Hospital Medical Information Network (UMIN) ID000010663
- Subjects :
- Blood Glucose
Male
lcsh:Medicine
Type 2 diabetes
Biochemistry
law.invention
Endocrinology
0302 clinical medicine
Randomized controlled trial
law
Diabetes diagnosis and management
Insulin
Medicine
030212 general & internal medicine
Medical nutrition therapy
lcsh:Science
Multidisciplinary
Organic Compounds
Poor glycemic control
Middle Aged
Type 2 Diabetes
Chemistry
Physical Sciences
Female
Research Article
medicine.medical_specialty
HbA1c
Drug Research and Development
Endocrine Disorders
Diet therapy
Carbohydrates
030209 endocrinology & metabolism
Research and Analysis Methods
03 medical and health sciences
Internal medicine
Diabetes mellitus
Dietary Carbohydrates
Diabetes Mellitus
Humans
Clinical Trials
In patient
Hemoglobin
Aged
Nutrition
Medicine and health sciences
Pharmacology
Diabetic Endocrinology
Biology and life sciences
business.industry
Organic Chemistry
lcsh:R
Chemical Compounds
Proteins
nutritional and metabolic diseases
Type 2 Diabetes Mellitus
medicine.disease
Diagnostic medicine
Randomized Controlled Trials
Hormones
Diabetes Mellitus, Type 2
Diet and Type 2 Diabetes
Metabolic Disorders
lcsh:Q
Clinical Medicine
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 19326203 and 00001066
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....b8e240eee26243d6573aa7c94c03097d
- Full Text :
- https://doi.org/10.1371/journal.pone.0188892