Back to Search Start Over

One year follow-up after a randomized controlled trial of a 130 g/day low-carbohydrate diet in patients with type 2 diabetes mellitus and poor glycemic control

One year follow-up after a randomized controlled trial of a 130 g/day low-carbohydrate diet in patients with type 2 diabetes mellitus and poor glycemic control

Authors :
Takeshi Ogihara
Chie Hatae
Takeshi Miyatsuka
Tomoaki Shimizu
Kiyoe Kobayashi
Yoshiko Miura
Hirotaka Watada
Tomoya Mita
Manami Iwaoka
Yoshifumi Tamura
Hiromasa Goto
Sumiko Makita
Koji Komiya
Akio Kanazawa
Takehito Watanabe
Nao Hirashima
Fuki Ikeda
Junko Sato
Toyoyoshi Uchida
Chie Ohmura
Source :
PLoS ONE, Vol 12, Iss 12, p e0188892 (2017), PLoS ONE
Publication Year :
2017
Publisher :
Public Library of Science (PLoS), 2017.

Abstract

Background & aims Recently, we conducted a prospective randomized controlled trial (RCT) showing that a 6-month 130g/day low-carbohydrate diet (LCD) reduced HbA1c and BMI more than a calorie restricted diet (CRD). [1] To assess whether the benefits of the LCD persisted after the intensive intervention, we compared HbA1c and BMI between the LCD and CRD groups at 1 year after the end of the 6-month RCT. Methods Following the end of the 6-month RCT, patients were allowed to manage their own diets with periodic outpatient visits. One year later, we analyzed clinical and nutrition data. Results Of the 66 participants in the original study, 27 in the CRD group and 22 in the LCD group completed this trial. One year after the end of the original RCT, the carbohydrate intake was comparable between the groups (215 [189–243]/day in the CRD group and 214 (176–262) g/day in the LCD group). Compared with the baseline data, HbA1c and BMI were decreased in both groups (CRD: HbA1c -0.4 [-0.9 to 0.3] % and BMI -0.63 [-1.20 to 0.18] kg/m2; LCD: HbA1c -0.35 [-1.0 to 0.35] % and BMI -0.77 [-1.15 to -0.12] kg/m2). There were no significant differences in HbA1c and BMI between the groups. Conclusions One year after the diet therapy intervention, the beneficial effect of the LCD on reduction of HbA1c and BMI did not persist in comparison with CRD. However, combining the data of both groups, significant improvements in HbA1c and BMI from baseline were observed. Although the superiority of the LCD disappeared 1 year after the intensive intervention, these data suggest that well-constructed nutrition therapy programs, both CRD and LCD, were equally effective in improving HbA1c for at least 1 year. Trial registration University Hospital Medical Information Network (UMIN) ID000010663

Details

ISSN :
19326203 and 00001066
Volume :
12
Database :
OpenAIRE
Journal :
PLOS ONE
Accession number :
edsair.doi.dedup.....b8e240eee26243d6573aa7c94c03097d
Full Text :
https://doi.org/10.1371/journal.pone.0188892