Back to Search
Start Over
Tuning InAs Nanowire Density for HEK293 Cell Viability, Adhesion, and Morphology: Perspectives for Nanowire-Based Biosensors
- Source :
- ACS Applied Materials & Interfaces. 5:10510-10519
- Publication Year :
- 2013
- Publisher :
- American Chemical Society (ACS), 2013.
-
Abstract
- Arrays of nanowires (NWs) are currently being established as vehicles for molecule delivery and electrical- and fluorescence-based platforms in the development of biosensors. It is conceivable that NW-based biosensors can be optimized through increased understanding of how the nanotopography influences the interfaced biological material. Using state-of-the-art homogenous NW arrays allow for a systematic investigation of how the broad range of NW densities used by the community influences cells. Here it is demonstrated that indium arsenide NW arrays provide a cell-promoting surface, which affects both cell division and focal adhesion up-regulation. Furthermore, a systematic variation in NW spacing affects both the detailed cell morphology and adhesion properties, where the latter can be predicted based on changes in free-energy states using the proposed theoretical model. As the NW density influences cellular parameters, such as cell size and adhesion tightness, it will be important to take NW density into consideration in the continued development of NW-based platforms for cellular applications, such as molecule delivery and electrical measurements.
- Subjects :
- Materials science
Cell Survival
Nanowires
Surface Properties
Nanowire
Nanotechnology
Biosensing Techniques
Adhesion
Cell morphology
Indium
Arsenicals
chemistry.chemical_compound
HEK293 Cells
chemistry
Cell Adhesion
Humans
General Materials Science
Nanorod
Nanotopography
Indium arsenide
Cell adhesion
Nanopillar
Subjects
Details
- ISSN :
- 19448252 and 19448244
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- ACS Applied Materials & Interfaces
- Accession number :
- edsair.doi.dedup.....b8f8e4e2498664f797d379e1e93ae192