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Predictors of the CD24/CD11b Biomarker among Healthy Subjects

Predictors of the CD24/CD11b Biomarker among Healthy Subjects

Authors :
Jacob Mashiah
Fatin Mdah
Nadir Arber
Gal Aiger
Amitay Ohayon
Shahar Lev-Ari
Lian Banon
Marina Ben Shimon
Shiran Shapira
Dina Kazanov
Mori Hay-Levy
Ido Laskov
Source :
Journal of Personalized Medicine, Volume 11, Issue 9, Journal of Personalized Medicine, Vol 11, Iss 939, p 939 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

The CD24 gene has raised considerable interest in tumor biology as a new prognostic factor and a biomarker for the early detection of cancer. There are currently no studies that assess predictors of CD24 in blood tests among healthy individuals. Our aims were (1) to evaluate predictors of the CD24/CD11b biomarker among healthy subjects and (2) to assess CD24/CD11b levels of participants with and without benign tumors. Our cohort included 1640 healthy subjects, aged 20–85, recruited at the Health Promotion and Integrated Cancer Prevention Center (ICPC) in the Tel Aviv Medical Center. Eligible subjects completed a detailed questionnaire on medical history and other epidemiologic information. CD24/CD11b expression in peripheral blood leukocytes (PBLs) obtained from blood samples of participants was analyzed by flow cytometry. Our results showed that the average levels of CD24/CD11b in healthy patients (22.8 ± 9.3) was statistically significant lower compared to subjects with benign cancers (26.1 ± 10.5, p &lt<br />0.001). Our multivariable analysis demonstrated that elevated levels of CRP (coefficient β: 1.98, p = 0.011) were significantly associated with high levels of CD24/CD11b expression among healthy participants. Other risk factors of cancer were not associated with elevated CD24 levels among healthy subjects. In conclusion, our findings may assist in further development and optimization of the CD24/CD11b biomarker to serve as a cancer screening test for early detection of cancer among the healthy population.

Details

ISSN :
20754426
Volume :
11
Database :
OpenAIRE
Journal :
Journal of Personalized Medicine
Accession number :
edsair.doi.dedup.....b901440279e22c6049e3883bc1741fde
Full Text :
https://doi.org/10.3390/jpm11090939