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Moving forward with isoprostanes, neuroprostanes and phytoprostanes: where are we now?
- Source :
- Essays in Biochemistry, Essays in Biochemistry, Portland Press, 2020, 64 (3), pp.463-484. ⟨10.1042/EBC20190096⟩
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- Polyunsaturated fatty acids (PUFAs) are essential components in eukaryotic cell membrane. They take part in the regulation of cell signalling pathways and act as precursors in inflammatory metabolism. Beside these, PUFAs auto-oxidize through free radical initiated mechanism and release key products that have various physiological functions. These products surfaced in the early nineties and were classified as prostaglandin isomers or isoprostanes, neuroprostanes and phytoprostanes. Although these molecules are considered robust biomarkers of oxidative damage in diseases, they also contain biological activities in humans. Conceptual progress in the last 3 years has added more understanding about the importance of these molecules in different fields. In this chapter, a brief overview of the past 30 years and the recent scope of these molecules, including their biological activities, biosynthetic pathways and analytical approaches are discussed.
- Subjects :
- 01 natural sciences
Biochemistry
Oxidative damage
Lipid peroxidation
03 medical and health sciences
chemistry.chemical_compound
Fatty Acids, Omega-6
Humans
Neuroprostanes
[CHIM]Chemical Sciences
Molecular Biology
Eukaryotic cell
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
chemistry.chemical_classification
0303 health sciences
Mechanism (biology)
010401 analytical chemistry
alpha-Linolenic Acid
Plants
Isoprostanes
0104 chemical sciences
Oxidative Stress
chemistry
Reactive Oxygen Species
Oxidation-Reduction
Biomarkers
Polyunsaturated fatty acid
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 00711365
- Database :
- OpenAIRE
- Journal :
- Essays in Biochemistry, Essays in Biochemistry, Portland Press, 2020, 64 (3), pp.463-484. ⟨10.1042/EBC20190096⟩
- Accession number :
- edsair.doi.dedup.....b9015d8977a543b1663258af71f9c7db