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Ocular damage effects from 1338-nm pulsed laser radiation in a rabbit eye model

Authors :
Jiarui Wang
Luguang Jiao
Hongxia Chen
Zaifu Yang
Xiaomin Jing
Source :
Biomedical Optics Express. 8:2745
Publication Year :
2017
Publisher :
The Optical Society, 2017.

Abstract

The ocular damage effects induced by transitional near-infrared (NIR) lasers have been investigated for years. However, no retinal damage thresholds are determined in a wide interval between 0.65 ms and 80 ms, and a definite relationship between corneal damage threshold and spot size cannot be drawn from existing data points. In this paper, the in-vivo corneal damage thresholds (ED50s) were determined in New Zealand white rabbits for a single 5 ms pulse at the wavelength of 1338 nm for spot sizes from 0.28 mm to 3.55 mm. Meanwhile, the retinal damage threshold for this laser was determined in chinchilla grey rabbits under the condition that the beam was collimated, and the incident corneal spot diameter was 5.0 mm. The corneal ED50s given in terms of the corneal radiant exposure for spot diameters of 0.28, 0.94, 1.91, and 3.55 mm were 70.3, 35.6, 29.6 and 30.3 J/cm2, respectively. The retinal ED50 given in terms of total intraocular energy (TIE) was 0.904 J. The most sensitive ocular tissue to this laser changed from the cornea to retina with the increase of spot size.

Details

ISSN :
21567085
Volume :
8
Database :
OpenAIRE
Journal :
Biomedical Optics Express
Accession number :
edsair.doi.dedup.....b9016a1b9be0b6b0291f7654502ce5fc
Full Text :
https://doi.org/10.1364/boe.8.002745