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Ocular damage effects from 1338-nm pulsed laser radiation in a rabbit eye model
- Source :
- Biomedical Optics Express. 8:2745
- Publication Year :
- 2017
- Publisher :
- The Optical Society, 2017.
-
Abstract
- The ocular damage effects induced by transitional near-infrared (NIR) lasers have been investigated for years. However, no retinal damage thresholds are determined in a wide interval between 0.65 ms and 80 ms, and a definite relationship between corneal damage threshold and spot size cannot be drawn from existing data points. In this paper, the in-vivo corneal damage thresholds (ED50s) were determined in New Zealand white rabbits for a single 5 ms pulse at the wavelength of 1338 nm for spot sizes from 0.28 mm to 3.55 mm. Meanwhile, the retinal damage threshold for this laser was determined in chinchilla grey rabbits under the condition that the beam was collimated, and the incident corneal spot diameter was 5.0 mm. The corneal ED50s given in terms of the corneal radiant exposure for spot diameters of 0.28, 0.94, 1.91, and 3.55 mm were 70.3, 35.6, 29.6 and 30.3 J/cm2, respectively. The retinal ED50 given in terms of total intraocular energy (TIE) was 0.904 J. The most sensitive ocular tissue to this laser changed from the cornea to retina with the increase of spot size.
- Subjects :
- medicine.medical_specialty
Materials science
genetic structures
Laser safety
01 natural sciences
Article
Collimated light
law.invention
010309 optics
030207 dermatology & venereal diseases
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Optics
law
Ophthalmology
Cornea
0103 physical sciences
medicine
Retina
Pulse (signal processing)
business.industry
Retinal
Laser
eye diseases
Atomic and Molecular Physics, and Optics
Wavelength
medicine.anatomical_structure
chemistry
sense organs
business
Biotechnology
Subjects
Details
- ISSN :
- 21567085
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Biomedical Optics Express
- Accession number :
- edsair.doi.dedup.....b9016a1b9be0b6b0291f7654502ce5fc
- Full Text :
- https://doi.org/10.1364/boe.8.002745