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Formyl-Peptide Receptor Activation Enhances Phagocytosis of Community-Acquired Methicillin-Resistant Staphylococcus aureus
- Source :
- The Journal of Infectious Diseases.
- Publication Year :
- 2019
- Publisher :
- Oxford University Press (OUP), 2019.
-
Abstract
- BackgroundFormyl-peptide receptors (FPRs) are important pattern recognition receptors that sense specific bacterial peptides. Formyl-peptide receptors are highly expressed on neutrophils and monocytes, and their activation promotes the migration of phagocytes to sites of infection. It is currently unknown whether FPRs may also influence subsequent processes such as bacterial phagocytosis and killing. Staphylococcus aureus, especially highly pathogenic community-acquired methicillin-resistant S aureus strains, release high amounts of FPR2 ligands, the phenol-soluble modulins.MethodsWe demonstrate that FPR activation leads to upregulation of complement receptors 1 and 3 as well as FCγ receptor I on neutrophils and, consequently, increased opsonic phagocytosis of S aureus and other pathogens.ResultsIncreased phagocytosis promotes killing of S aureus and interleukin-8 release by neutrophils.ConclusionsWe show here for the first time that FPRs govern opsonic phagocytosis. Manipulation of FPR2 activation could open new therapeutic opportunities against bacterial pathogens.
- Subjects :
- Methicillin-Resistant Staphylococcus aureus
0301 basic medicine
Neutrophils
Phagocytosis
Fc receptor
Macrophage-1 Antigen
Blood Donors
Complement receptor
medicine.disease_cause
Microbiology
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Immunology and Allergy
Receptors, Lipoxin
Receptor
Opsonin
Cells, Cultured
Formyl peptide receptor
biology
Chemistry
Interleukin-8
Receptors, IgG
Pattern recognition receptor
Staphylococcal Infections
Receptors, Formyl Peptide
Community-Acquired Infections
030104 developmental biology
Infectious Diseases
Staphylococcus aureus
Receptors, Pattern Recognition
Receptors, Complement 3b
biology.protein
030215 immunology
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Database :
- OpenAIRE
- Journal :
- The Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....b90f582059b3ada58dd10cb5707b1b1f