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The transmission disequilibrium test and imprinting effects test based on case-parent pairs
The transmission disequilibrium test and imprinting effects test based on case-parent pairs
- Source :
- Genetic Epidemiology. 31:273-287
- Publication Year :
- 2007
- Publisher :
- Wiley, 2007.
-
Abstract
- The transmission disequilibrium test (TDT) based on case-parents trios is a powerful tool in linkage analysis and association studies. When only one parent is available, the 1-TDT is applicable in the absence of imprinting. In the presence of imprinting, a statistic is proposed, based on case-mother pairs and case-father pairs to test for linkage when association is present as well as to test for association when linkage is present. The recombination fractions are allowed to be sex-specific in this test statistic. Meanwhile, a statistic based on case-parent pairs is proposed to test for imprinting. Both test statistics can be extended to include families with more than one affected offspring. A number of simulation studies are conducted to investigate the validity of the proposed tests. The effects of different ratios of the numbers of case-mother pairs and casefather pairs on the powers of the proposed tests are studied through simulation. The results show that the optimal ratio is 1:1. How to combine case-parents, case-mother pairs, and case-father pairs jointly in testing for linkage, association, and imprinting is addressed. Genet. Epidemiol. 31:273–287, 2007. r 2007 Wiley-Liss, Inc.
- Subjects :
- Male
Parents
Linkage disequilibrium
Models, Genetic
Epidemiology
Mothers
Transmission disequilibrium test
Biology
Population stratification
Linkage Disequilibrium
Fathers
Genomic Imprinting
Genetic Techniques
Statistics
Test statistic
Humans
Computer Simulation
Female
Imprinting (psychology)
Genetics (clinical)
Statistic
Statistical hypothesis testing
Genetic association
Subjects
Details
- ISSN :
- 10982272 and 07410395
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Genetic Epidemiology
- Accession number :
- edsair.doi.dedup.....b938e6d12f330ddc01455d23a7afb51e
- Full Text :
- https://doi.org/10.1002/gepi.20208