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Gadolinium retention within multiple rat organs after intra-articular administration of gadolinium-based contrast agents
- Source :
- Skeletal Radiology
- Publication Year :
- 2020
-
Abstract
- Objective To characterize the extent of retention and biodistribution of gadolinium (Gd) following intra-articular (IA) injection of linear and macrocyclic gadolinium-based contrast agents (GBCAs) into the knee joint of a rat model. Materials and methods Fifteen Wistar rats were divided into five groups and underwent fluoroscopically-guided injections of both knee joints of (1) clinical 1:200 dilution (low dose, LD) gadodiamide (linear GBCA), (2) LD gadobutrol (macrocyclic GBCA), (3) undiluted (high dose, HD) gadodiamide, (4) HD gadobutrol, and (5) saline. Gd concentrations were quantified by inductively coupled plasma mass spectrometry in (1) blood and urine samples obtained over a 72 h period and (2) knee joint tissues, brain, kidney, and bone marrow at 3 days post-injection. Results Both HD and LD gadodiamide and gadobutrol were rapidly absorbed from the joint with peak serum and urine concentration at 1 h post-injection, with relatively faster clearance of gadobutrol. All GBCA-exposed groups had detectable levels of Gd in the joint tissues, bone marrow, and/or kidneys (median tissue gadolinium range: 0.1–71 μg Gd/g tissue), with higher amounts observed with gadodiamide versus gadobutrol. Retention within brain tissues was only detected following HD gadodiamide administration but not LD gadodiamide nor HD or LD gadobutrol. Conclusion There was rapid systemic absorption, redistribution, and widespread multi-organ retention of Gd following IA injection of both linear and macrocyclic GBCAs, despite substantial amounts of urinary excretion. Higher concentrations of Gd were observed with administration of gadodiamide compared to gadobutrol in most tissues and biofluids.
- Subjects :
- Gadolinium DTPA
Biodistribution
Gadolinium
medicine.medical_treatment
chemistry.chemical_element
Urine
030218 nuclear medicine & medical imaging
Gadobutrol
03 medical and health sciences
0302 clinical medicine
medicine
Organometallic Compounds
Animals
Radiology, Nuclear Medicine and imaging
Tissue Distribution
Scientific Article
Rats, Wistar
Arthrography
Saline
Kidney
medicine.diagnostic_test
business.industry
Gadodiamide
Contrast media
Brain
Magnetic resonance imaging
Magnetic Resonance Imaging
Rats
medicine.anatomical_structure
chemistry
030220 oncology & carcinogenesis
Nuclear medicine
business
medicine.drug
Subjects
Details
- ISSN :
- 14322161
- Volume :
- 50
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Skeletal radiology
- Accession number :
- edsair.doi.dedup.....b939ead54f8e8b80602d44ee3c3ab5ce