Design and Synthesis of 2,3,5-Substituted Imidazolidin-4-one Inhibitors of BACE-1

Authors :: Samuel L. Graham
Amy S. Espeseth
Kenneth E. Rittle
Katherine Tugusheva
Dennis Colussi
Phung L. Ngo
Ming Tain Lai
Georgia B. McGaughey
Steven M. Pitzenberger
Harold G. Selnick
Qian Huang
Joseph P. Vacca
Adam J. Simon
Sanjeev Munshi
James C. Barrow
Source :: ChemMedChem. 2:995-999
Publication Year :: 2007
Publisher :: Wiley, 2007.

Subjects :: Models, Molecular
Pharmacology
Binding Sites
Chemistry
Stereochemistry
Organic Chemistry
Hydrogen Bonding
Crystallography, X-Ray
Imidazolidines
Biochemistry
Mass Spectrometry
Drug Discovery
Hydrolase
β secretase
Aspartic Acid Endopeptidases
Molecular Medicine
Protease Inhibitors
Amyloid Precursor Protein Secretases
General Pharmacology, Toxicology and Pharmaceutics

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