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Prenatal exposure to cigarette smoke and anogenital distance at 4 years in the INMA‐Asturias cohort
Prenatal exposure to cigarette smoke and anogenital distance at 4 years in the INMA‐Asturias cohort
- Source :
- Scopus, International Journal of Environmental Research and Public Health, Vol 18, Iss 4774, p 4774 (2021), RUO. Repositorio Institucional de la Universidad de Oviedo, instname, Addi. Archivo Digital para la Docencia y la Investigación, International Journal of Environmental Research and Public Health, Addi: Archivo Digital para la Docencia y la Investigación, Universidad del País Vasco, Volume 18, Issue 9
- Publication Year :
- 2021
-
Abstract
- Smoking by women is associated with adverse pregnancy outcomes such as spontaneous abortion, preterm delivery, low birth weight, infertility, and prolonged time to pregnancy. Anogenital distance (AGD) is a sensitive biomarker of prenatal androgen and antiandrogen exposure. We investigated the effect of smoking and passive smoke exposure during pregnancy on anogenital distance in offspring at 4 years in the INMA-Asturias cohort (Spain). Women were interviewed during pregnancy to collect information on tobacco consumption, and anogenital distance was measured in 381 children: Anoscrotal distance in boys and anofourchetal distance in girls. We also measured maternal urinary cotinine levels at 32 weeks of pregnancy. We constructed linear regression models to analyze the association between prenatal smoke exposure and anogenital distance and adjusted the models by relevant covariates. Reported prenatal smoke exposure was associated with statistically significant increased anogenital index (AGI), both at week 12 of pregnancy (β = 0.31, 95% confidence interval: 0.00, 0.63) and at week 32 of pregnancy (β = 0.31, 95% confidence interval: 0.00, 0.63) in male children, suggesting altered androgenic signaling. Funding was provided by CIBERESP (PhD employment contract and fellowship for short stays abroad—2019), FIS-FEDER (grants PI04/2018, PI09/02311, PI13/02429, and PI18/00909), Obra Social Cajastur/Fundación Liberbank, and Universidad de Oviedo.
- Subjects :
- Male
medicine.medical_specialty
Offspring
Health, Toxicology and Mutagenesis
Anal Canal
Article
maternal cigarette smoking
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Pregnancy
Smoke
Medicine
Humans
030212 general & internal medicine
anogenital distance
tobacco smoking
Child
endocrine-disrupting chemicals
030219 obstetrics & reproductive medicine
business.industry
Obstetrics
Anogenital distance
Smoking
Public Health, Environmental and Occupational Health
Infant, Newborn
medicine.disease
Confidence interval
Passive Smoke Exposure
Low birth weight
chemistry
Maternal Exposure
Spain
Prenatal Exposure Delayed Effects
Cohort
Female
medicine.symptom
business
Cotinine
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Scopus, International Journal of Environmental Research and Public Health, Vol 18, Iss 4774, p 4774 (2021), RUO. Repositorio Institucional de la Universidad de Oviedo, instname, Addi. Archivo Digital para la Docencia y la Investigación, International Journal of Environmental Research and Public Health, Addi: Archivo Digital para la Docencia y la Investigación, Universidad del País Vasco, Volume 18, Issue 9
- Accession number :
- edsair.doi.dedup.....b9584bbce98cfc59a8b9a10862ed6468