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Prenatal exposure to cigarette smoke and anogenital distance at 4 years in the INMA‐Asturias cohort

Prenatal exposure to cigarette smoke and anogenital distance at 4 years in the INMA‐Asturias cohort

Authors :
Rocío Fernández-Iglesias
Adonina Tardón
Isolina Riaño-Galán
Ana Fernández-Somoano
Izaro Babarro
Miguel García-Villarino
Cristina Rodriguez-Dehli
Source :
Scopus, International Journal of Environmental Research and Public Health, Vol 18, Iss 4774, p 4774 (2021), RUO. Repositorio Institucional de la Universidad de Oviedo, instname, Addi. Archivo Digital para la Docencia y la Investigación, International Journal of Environmental Research and Public Health, Addi: Archivo Digital para la Docencia y la Investigación, Universidad del País Vasco, Volume 18, Issue 9
Publication Year :
2021

Abstract

Smoking by women is associated with adverse pregnancy outcomes such as spontaneous abortion, preterm delivery, low birth weight, infertility, and prolonged time to pregnancy. Anogenital distance (AGD) is a sensitive biomarker of prenatal androgen and antiandrogen exposure. We investigated the effect of smoking and passive smoke exposure during pregnancy on anogenital distance in offspring at 4 years in the INMA-Asturias cohort (Spain). Women were interviewed during pregnancy to collect information on tobacco consumption, and anogenital distance was measured in 381 children: Anoscrotal distance in boys and anofourchetal distance in girls. We also measured maternal urinary cotinine levels at 32 weeks of pregnancy. We constructed linear regression models to analyze the association between prenatal smoke exposure and anogenital distance and adjusted the models by relevant covariates. Reported prenatal smoke exposure was associated with statistically significant increased anogenital index (AGI), both at week 12 of pregnancy (β = 0.31, 95% confidence interval: 0.00, 0.63) and at week 32 of pregnancy (β = 0.31, 95% confidence interval: 0.00, 0.63) in male children, suggesting altered androgenic signaling. Funding was provided by CIBERESP (PhD employment contract and fellowship for short stays abroad—2019), FIS-FEDER (grants PI04/2018, PI09/02311, PI13/02429, and PI18/00909), Obra Social Cajastur/Fundación Liberbank, and Universidad de Oviedo.

Details

Language :
English
Database :
OpenAIRE
Journal :
Scopus, International Journal of Environmental Research and Public Health, Vol 18, Iss 4774, p 4774 (2021), RUO. Repositorio Institucional de la Universidad de Oviedo, instname, Addi. Archivo Digital para la Docencia y la Investigación, International Journal of Environmental Research and Public Health, Addi: Archivo Digital para la Docencia y la Investigación, Universidad del País Vasco, Volume 18, Issue 9
Accession number :
edsair.doi.dedup.....b9584bbce98cfc59a8b9a10862ed6468