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Autophagy takes flight inDrosophila
- Source :
- FEBS Letters. 584:1342-1349
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- Drosophila has been shown to be a powerful model to study autophagy, whose regulation involves a core machinery consisting of Atg proteins and upstream signaling regulators similar to those in yeast and mammals. The conserved role in degrading proteins and organelles gives autophagy an important function in coordinating several cellular processes as well as in a number of pathological conditions. This review summarizes key studies in Drosophila autophagy research and discusses potential questions that may lead to better understanding of the roles and regulation of autophagy in higher eukaryotes.
- Subjects :
- Atg1
Autophagy-related gene 1
Biophysics
Apoptosis
Unc-51 like kinase 1
Biochemistry
Article
Vps34
Structural Biology
Autophagy
Genetics
Animals
Drosophila Proteins
Molecular Biology
PI3K/AKT/mTOR pathway
biology
Autophagy database
TOR Serine-Threonine Kinases
Jun-N-terminal kinase
Cell Biology
ULK1
biology.organism_classification
Cell biology
Oxidative Stress
Drosophila melanogaster
Target of rapamycin
Nerve Degeneration
Protein Kinases
Function (biology)
Drosophila Protein
Subjects
Details
- ISSN :
- 00145793
- Volume :
- 584
- Database :
- OpenAIRE
- Journal :
- FEBS Letters
- Accession number :
- edsair.doi.dedup.....b9595ee7ca90ba8bcc8d49c642f2f495