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The Association between Insomnia-Like Sleep Pattern Changes and Cognitive Dysfunction: Possible Mechanism and Therapeutic Strategy

Authors :
Kangzhi, Chen
Yefan, Lv
Xiaoyan, Long
Weiping, Liu
Jinxia, Zhou
Source :
Current Alzheimer Research. 18:858-875
Publication Year :
2021
Publisher :
Bentham Science Publishers Ltd., 2021.

Abstract

The prevalence of sleep disorders and cognitive dysfunction has overwhelmingly increased, with insomnia and Alzheimer’s disease (AD) being the most common form. A multitude of studies have linked the alterations in sleep continuity or sleep architecture with cognitive impairment bilaterally, but the management of disrupted sleep patterns in preclinical AD could be more beneficial since there is no cure for AD. This review mainly focuses on the altered sleep patterns in insomnia, and summarizes potential pathways underlying the relationship between insomnia and cognitive impairment, aiming to establish certain sleep pattern changes as biomarkers for cognitive decline and explore potential therapeutic targets based on evidence from research advances.

Details

ISSN :
15672050
Volume :
18
Database :
OpenAIRE
Journal :
Current Alzheimer Research
Accession number :
edsair.doi.dedup.....b96ffe6c5c133f45fc2b6f58fa655587