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Prognostic Significance of Tumor Doubling Time in Mass-Forming Type Cholangiocarcinoma
- Source :
- Journal of gastrointestinal surgery 17 (2013): 739–747. doi:10.1007/s11605-012-2129-6, info:cnr-pdr/source/autori:De Rose AM, Cucchetti A, Clemente G, Ardito F, Giovannini I, Ercolani G, Giuliante F, Pinna AD, Nuzzo, G/titolo:Prognostic Significance of Tumor Doubling Time in Mass-Forming Type Cholangiocarcinoma/doi:10.1007%2Fs11605-012-2129-6/rivista:Journal of gastrointestinal surgery/anno:2013/pagina_da:739/pagina_a:747/intervallo_pagine:739–747/volume:17
- Publication Year :
- 2013
- Publisher :
- Quality Medical Pub., St. Louis, MO , Stati Uniti d'America, 2013.
-
Abstract
- OBJECTIVE: The aim of this study was to determine the prognostic significance of the preoperatively assessed tumor doubling time (DT) in patients undergoing liver resection for mass-forming intrahepatic cholangiocarcinoma (IHC). METHODS: We evaluated 79 patients who underwent curative resection for IHC, and in whom the same imaging technique was preoperatively available in two consecutive occasions, to allow the calculation of the DT. The influence of DT and other clinical and pathological variables on tumor recurrence and patient survival was determined by the Kaplan-Meier method and uni- and multivariate analysis. RESULTS: Median overall survival was 40 months; 1-, 3-, and 5-year survival rates were 86.1, 55.1, and 35.1 %, respectively. Median disease-free survival was 17 months; 1-, 3-, and 5-year disease-free survival rates were 62.0, 29.1, and 23.3 %, respectively. At univariate analysis, DT
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
Multivariate analysis
Settore MED/18 - CHIRURGIA GENERALE
DOUBLING TIME
Gastroenterology
Cholangiocarcinoma
Tumor doubling time
Internal medicine
HEPATIC SURGERY
Humans
Medicine
Doubling time
Pathological
Survival rate
Intrahepatic Cholangiocarcinoma
Aged
Intrahepatic cholangiocarcinoma
Aged, 80 and over
Univariate analysis
Liver resection
business.industry
HEPATOBILIARY DISEASES
Patient survival
Middle Aged
Prognosis
Tumor Burden
Survival Rate
Bile Ducts, Intrahepatic
Bile Duct Neoplasms
Immunohistochemistry
Female
Surgery
business
ANALYSIS OF SURVIVAL
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of gastrointestinal surgery 17 (2013): 739–747. doi:10.1007/s11605-012-2129-6, info:cnr-pdr/source/autori:De Rose AM, Cucchetti A, Clemente G, Ardito F, Giovannini I, Ercolani G, Giuliante F, Pinna AD, Nuzzo, G/titolo:Prognostic Significance of Tumor Doubling Time in Mass-Forming Type Cholangiocarcinoma/doi:10.1007%2Fs11605-012-2129-6/rivista:Journal of gastrointestinal surgery/anno:2013/pagina_da:739/pagina_a:747/intervallo_pagine:739–747/volume:17
- Accession number :
- edsair.doi.dedup.....b97a6b6f7798af88b6e147f4a3dd6af0
- Full Text :
- https://doi.org/10.1007/s11605-012-2129-6