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Evolving Concepts: How Diet and the Intestinal Microbiome Act as Modulators of Breast Malignancy
- Source :
- ISRN Oncology
- Publication Year :
- 2013
- Publisher :
- Hindawi Limited, 2013.
-
Abstract
- The intestinal microbiome plays an important role in human physiology. Next-generation sequencing technologies, knockout and gnotobiotic mouse models, fecal transplant data and epidemiologic studies have accelerated our understanding of microbiome abnormalities seen in immune diseases and malignancies. Dysbiosis is the disturbed microbiome ecology secondary to external pressures such as host diseases, medications, diet and genetic conditions often leading to abnormalities of the host immune system. Specifically dysbiosis has been shown to lower circulating lymphocytes, and increase neutrophil to lymphocyte ratio, a finding which has been associated with a decreased survival in women with breast cancers. Dysbiosis also plays a role in the recycling of estrogens via the entero-hepatic circulation, increasing estrogenic potency in the host, which is another leading cause of breast malignancy. Non-modifiable factors such as age and genetic mutations disrupt the microbiome, but modifiable factors such as diet may also lead to profound disruptions as well. A better understanding of dietary factors and how they disrupt the microbiome may lead to beneficial nutritional interventions for breast cancer patients.
- Subjects :
- 0303 health sciences
business.industry
Dietary factors
Review Article
Breast malignancy
medicine.disease
Bioinformatics
3. Good health
03 medical and health sciences
0302 clinical medicine
Breast cancer
Immune system
030220 oncology & carcinogenesis
Immunology
Intestinal Microbiome
Medicine
Microbiome
Neutrophil to lymphocyte ratio
business
Dysbiosis
030304 developmental biology
Subjects
Details
- ISSN :
- 2090567X
- Volume :
- 2013
- Database :
- OpenAIRE
- Journal :
- ISRN Oncology
- Accession number :
- edsair.doi.dedup.....b9805a9c59c890eda41c0b8de597ba08