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Perihematoma cerebral blood flow is unaffected by statin use in acute intracerebral hemorrhage patients
- Source :
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 35(7)
- Publication Year :
- 2014
-
Abstract
- Statin therapy has been associated with improved cerebral blood flow (CBF) and decreased perihematoma edema in animal models of intracerebral hemorrhage (ICH). We aimed to assess the relationship between statin use and cerebral hemodynamics in ICH patients. A post hoc analysis of 73 ICH patients enrolled in the Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial (ICH ADAPT). Patients presenting < 24 hours from ICH onset were randomized to a systolic blood pressure target < 150 or < 180 mm Hg with computed tomography perfusion imaging 2 hours after randomization. Cerebral blood flow maps were calculated. Hematoma and edema volumes were measured planimetrically. Regression models were used to assess the relationship between statin use, perihematoma edema and cerebral hemodynamics. Fourteen patients (19%) were taking statins at the time of ICH. Statin-treated patients had similar median (IQR Q25 to 75) hematoma volumes (21.1 (9.5 to 38.3) mL versus 14.5 (5.6 to 27.7) mL, P = 0.25), but larger median (IQR Q25 to 75) perihematoma edema volumes (2.9 (1.7 to 9.0) mL versus 2.2 (0.8 to 3.5) mL, P = 0.02) compared with nontreated patients. Perihematoma and ipsilateral hemispheric CBF were similar in both groups. A multivariate linear regression model revealed that statin use and hematoma volumes were independent predictors of acute edema volumes. Statin use does not affect CBF in ICH patients. Statin use, along with hematoma volume, are independently associated with increased perihematoma edema volume.
- Subjects :
- Male
Randomization
Perfusion Imaging
Perfusion scanning
Brain Edema
Hematoma
Edema
Post-hoc analysis
medicine
Humans
cardiovascular diseases
Aged
Cerebral Hemorrhage
Intracerebral hemorrhage
Aged, 80 and over
business.industry
Middle Aged
medicine.disease
Blood pressure
Neurology
Cerebral blood flow
Anesthesia
Cerebrovascular Circulation
Acute Disease
Female
Original Article
Neurology (clinical)
medicine.symptom
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cardiology and Cardiovascular Medicine
business
Tomography, X-Ray Computed
Subjects
Details
- ISSN :
- 15597016
- Volume :
- 35
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
- Accession number :
- edsair.doi.dedup.....b9afca39a1014550abcf927de837b51d