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Different cholesterol deposition in aorta of Dahl salt-sensitive rats and spontaneously hypertensive rats fed a high-cholesterol diet
Different cholesterol deposition in aorta of Dahl salt-sensitive rats and spontaneously hypertensive rats fed a high-cholesterol diet
- Source :
- Clinical and experimental pharmacologyphysiology. Supplement. 22(1)
- Publication Year :
- 1995
-
Abstract
- 1. We compared the serum and aortic lipid levels in spontaneously hypertensive rats (SHR) and Dahl salt-sensitive rats (DSR) fed a high-cholesterol (HC) diet. 2. In SHR fed the HC diet, the serum cholesterol level significantly increased, but no aortic cholesterol deposition was observed. 3. The serum cholesterol level in DSR fed the HC diet markedly increased compared to that in DSR fed the basal diet, and this change was greater with the diet containing 8% NaCl than 0.4% NaCl. A significant increase in the content of aortic cholesterol, notably cholesteryl ester, was observed in only DSR fed the HC diet containing 8% NaCl. 4. These results suggest that the combination of hypercholesterolaemia with salt-induced hypertension acts as a greater risk factor for atherosclerosis than that with genetic hypertension.
- Subjects :
- Male
medicine.medical_specialty
Physiology
Sodium
Hypercholesterolemia
chemistry.chemical_element
Sodium Chloride
Cholesterol deposition
Rats, Inbred WKY
Cholesterol, Dietary
Basal (phylogenetics)
chemistry.chemical_compound
Spontaneously hypertensive rat
Physiology (medical)
medicine.artery
Internal medicine
Rats, Inbred SHR
medicine
Animals
Aorta, Abdominal
Pharmacology
Aorta
Cholesterol
Lipid metabolism
Rats, Inbred Strains
Lipid Metabolism
Diet
Rats
Endocrinology
chemistry
Hypertension
cardiovascular system
Cholesteryl ester
lipids (amino acids, peptides, and proteins)
Subjects
Details
- ISSN :
- 01439294
- Volume :
- 22
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Clinical and experimental pharmacologyphysiology. Supplement
- Accession number :
- edsair.doi.dedup.....b9b244a7b240d4af7c37a9db823b8771