Back to Search Start Over

Different cholesterol deposition in aorta of Dahl salt-sensitive rats and spontaneously hypertensive rats fed a high-cholesterol diet

Different cholesterol deposition in aorta of Dahl salt-sensitive rats and spontaneously hypertensive rats fed a high-cholesterol diet

Authors :
Young Mi Kwon
Yu Yamaguchi
Kazumasa Shinozuka
Satomi Kitagawa
Masaru Kunitomo
Source :
Clinical and experimental pharmacologyphysiology. Supplement. 22(1)
Publication Year :
1995

Abstract

1. We compared the serum and aortic lipid levels in spontaneously hypertensive rats (SHR) and Dahl salt-sensitive rats (DSR) fed a high-cholesterol (HC) diet. 2. In SHR fed the HC diet, the serum cholesterol level significantly increased, but no aortic cholesterol deposition was observed. 3. The serum cholesterol level in DSR fed the HC diet markedly increased compared to that in DSR fed the basal diet, and this change was greater with the diet containing 8% NaCl than 0.4% NaCl. A significant increase in the content of aortic cholesterol, notably cholesteryl ester, was observed in only DSR fed the HC diet containing 8% NaCl. 4. These results suggest that the combination of hypercholesterolaemia with salt-induced hypertension acts as a greater risk factor for atherosclerosis than that with genetic hypertension.

Details

ISSN :
01439294
Volume :
22
Issue :
1
Database :
OpenAIRE
Journal :
Clinical and experimental pharmacologyphysiology. Supplement
Accession number :
edsair.doi.dedup.....b9b244a7b240d4af7c37a9db823b8771