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Chemical Composition and Validation of the Ethnopharmacological Reported Antimicrobial Activity of the Body Fat ofPhrynops geoffroanusUsed in Traditional Medicine

Chemical Composition and Validation of the Ethnopharmacological Reported Antimicrobial Activity of the Body Fat ofPhrynops geoffroanusUsed in Traditional Medicine

Authors :
Olga Paiva Oliveira
Waltécio de Oliveira Almeida
Rômulo Romeu Nóbrega Alves
Diógenes de Queiroz Dias
João Antonio de Araujo Filho
Diêgo Alves Teles
José Guilherme G. Sousa
José Galberto Martins da Costa
Débora Lima Sales
Mario Eduardo Santos Cabral
Henrique Douglas Melo Coutinho
Marta Regina Kerntopf
Source :
Evidence-based Complementary and Alternative Medicine : eCAM, Evidence-Based Complementary and Alternative Medicine, Vol 2013 (2013)
Publication Year :
2013
Publisher :
Hindawi Limited, 2013.

Abstract

Background.Phrynops geoffroanusis a small turtle that inhabits lakes, rivers, and streams throughout South America. The body fat of this animal is used as a folk medicine in Brazil for treating illnesses such as sore throats, ear aches, mumps, rheumatism, and arthritis. The present study evaluated the antimicrobial activity of oil extracted fromPhrynops geoffroanus(OPG), determined its chemical composition, and discussed the implications of its use in traditional medicine. The OPG was obtained from the ventral region of this turtle using hexane as a solvent. The antimicrobial activity of OPG was tested against standard and multiresistance strains of bacteria and fungi and its composition was determined indirectly by analyzing the methyl esters of the component fatty acids. The OPG presented a clinically relevant antifungal activity againstCandida kruseiATCC 6258 (MIC 128 µg/mL). When the OPG was associated with the antibacterial and antifungal drugs, was observed a synergistic effect when associated the OPG with the gentamicin against the strainPseudomonas aeruginosa22. Our results indicated that OPG has clinically relevant antifungal activity againstC. krusei, and demonstrated synergetic antibacterial activity in combination with commercial antibiotics againstPseudomonas aeruginosa.

Details

ISSN :
17414288 and 1741427X
Volume :
2013
Database :
OpenAIRE
Journal :
Evidence-Based Complementary and Alternative Medicine
Accession number :
edsair.doi.dedup.....b9c80103e9b2911fc8e46739e80a28fe
Full Text :
https://doi.org/10.1155/2013/715040