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Chemical Composition and Validation of the Ethnopharmacological Reported Antimicrobial Activity of the Body Fat ofPhrynops geoffroanusUsed in Traditional Medicine
Chemical Composition and Validation of the Ethnopharmacological Reported Antimicrobial Activity of the Body Fat ofPhrynops geoffroanusUsed in Traditional Medicine
- Source :
- Evidence-based Complementary and Alternative Medicine : eCAM, Evidence-Based Complementary and Alternative Medicine, Vol 2013 (2013)
- Publication Year :
- 2013
- Publisher :
- Hindawi Limited, 2013.
-
Abstract
- Background.Phrynops geoffroanusis a small turtle that inhabits lakes, rivers, and streams throughout South America. The body fat of this animal is used as a folk medicine in Brazil for treating illnesses such as sore throats, ear aches, mumps, rheumatism, and arthritis. The present study evaluated the antimicrobial activity of oil extracted fromPhrynops geoffroanus(OPG), determined its chemical composition, and discussed the implications of its use in traditional medicine. The OPG was obtained from the ventral region of this turtle using hexane as a solvent. The antimicrobial activity of OPG was tested against standard and multiresistance strains of bacteria and fungi and its composition was determined indirectly by analyzing the methyl esters of the component fatty acids. The OPG presented a clinically relevant antifungal activity againstCandida kruseiATCC 6258 (MIC 128 µg/mL). When the OPG was associated with the antibacterial and antifungal drugs, was observed a synergistic effect when associated the OPG with the gentamicin against the strainPseudomonas aeruginosa22. Our results indicated that OPG has clinically relevant antifungal activity againstC. krusei, and demonstrated synergetic antibacterial activity in combination with commercial antibiotics againstPseudomonas aeruginosa.
- Subjects :
- musculoskeletal diseases
Phrynops geoffroanus
Article Subject
biology
Traditional medicine
business.industry
Pseudomonas aeruginosa
medicine.drug_class
Antibiotics
lcsh:Other systems of medicine
lcsh:RZ201-999
Antimicrobial
biology.organism_classification
medicine.disease_cause
Complementary and alternative medicine
Candida krusei
medicine
Gentamicin
business
Antibacterial activity
Bacteria
Research Article
medicine.drug
Subjects
Details
- ISSN :
- 17414288 and 1741427X
- Volume :
- 2013
- Database :
- OpenAIRE
- Journal :
- Evidence-Based Complementary and Alternative Medicine
- Accession number :
- edsair.doi.dedup.....b9c80103e9b2911fc8e46739e80a28fe
- Full Text :
- https://doi.org/10.1155/2013/715040