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Elevated serum ferritin levels are associated with severity and prognosis of severe acute pancreatitis: a preliminary cohort study

Authors :
Jie Wang
Qing-xie Liu
Dong-ling Teng
Yan-bing Ding
Guo-tao Lu
Wei-juan Gong
Qing-tian Zhu
Fei Han
Wei-ming Xiao
Source :
BMC gastroenterology. 22(1)
Publication Year :
2022

Abstract

Background Serum ferritin (SF), as an acute-phase response protein, is used to reflect the degree of oxidative stress and systemic inflammatory responses. This study was designed to assess the effect of elevated SF levels on the severity of acute pancreatitis (AP). Methods From January 2013 to December 2020, 200 consecutive patients with AP were retrospectively reviewed to analyze the relationships among the etiologies of pancreatitis, the severity of the disease and SF levels. The receiver operating characteristic (ROC) curve and logistic regression analysis were used to assess whether elevated SF levels could predict the onset of organ failure in AP. Results 92 (46%) had high SF levels (> 275 ng/ml). SF levels were not associated with the etiology of AP disease. Among patients with high SF levels, there was a significant increase in the proportion of patients with severe AP (23.1% vs. 76.9%) and a higher proportion of systemic inflammatory response scores (25.9% vs. 44.6%) in comparison to patients with normal SF levels. The area under the ROC curve for SF in predicting persistent organ failure was 0.812 [95% confidence interval 0.721–0.904]. Conclusions F concentrations were positively correlated with the severity of AP, and quantitative assessment of SF can predict disease severity and organ failure in patients with AP.

Details

ISSN :
1471230X
Volume :
22
Issue :
1
Database :
OpenAIRE
Journal :
BMC gastroenterology
Accession number :
edsair.doi.dedup.....b9cc272199cde2327e0aea84fb956179