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Daphhimalenine A, a New Alkaloid with an Unprecedented Skeleton, from Daphniphyllum himalense
- Source :
- Organic Letters. 11:5414-5417
- Publication Year :
- 2009
- Publisher :
- American Chemical Society (ACS), 2009.
-
Abstract
- Daphhimalenine A (1), a novel alkaloid with a rearrangement C-21 skeleton, containing a unique 1-azabicyclo[5.2.1]decane ring system, was isolated from the leaves of Daphniphyllum himalense, along with biogenetically related alkaloids daphhimalenine B (2) and daphnezomine T. Their structures were established on the basis of spectroscopic data, and the absolute configuration of 1 was assigned by computational methods. A plausible biosynthetic pathway of 1 was also proposed.
- Subjects :
- Molecular Structure
biology
Stereochemistry
Chemistry
Alkaloid
Saxifragaceae
Organic Chemistry
Absolute configuration
Decane
Skeleton (category theory)
Ring (chemistry)
biology.organism_classification
Biochemistry
Plant Leaves
chemistry.chemical_compound
Alkaloids
Humans
Drug Screening Assays, Antitumor
Physical and Theoretical Chemistry
Nuclear Magnetic Resonance, Biomolecular
Daphniphyllum
Subjects
Details
- ISSN :
- 15237052 and 15237060
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Organic Letters
- Accession number :
- edsair.doi.dedup.....b9ee4d826ef37eb5b27839a8dd440fa2