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Associations of systolic and diastolic blood pressure night-to-day ratios with atherosclerotic cardiovascular diseases
- Source :
- Hypertension Research. 39:874-878
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Our objective was to evaluate the associations of the systolic and diastolic blood pressure night-to-day ratios (SBP-NDR and DBP-NDR) with composite atherosclerotic cardiovascular diseases (ASCVDs) comprising coronary heart disease (CHD) and ischemic stroke (IS) cases, respectively. The clinical conditions associated with SBP-NDR and DBP-NDR were also evaluated. A total of 401 patients who underwent 24-h ambulatory BP monitoring were enrolled. In general, the mean age was 59.7±14.7 years and male subjects accounted for 59.1% of the study subjects. Regarding the ASCVD risk factors, 17.0% of the study subjects smoked, 5.2% abused alcohol, 2.0% had a family history of ASCVD, 23.3% had diabetes and 96.0% had dyslipidemia. Fifty (12.5%) and 128 (31.9%) study subjects had a previous diagnosis of CHD and IS, respectively. Dipper and non-dipper pattern-specific differences in clinical characteristics between the SBP-NDR and DBP-NDR categories were observed. The multiple linear regression analysis showed that advanced age, smoking, CHD and IS were positively associated with SBP-NDR and statins were inversely associated with SBP-NDR; only IS was positively associated with DBP-NDR. The logistic regression analysis showed that after adjusting for the covariates of age, smoking, alcohol abuse, diabetes, hypertension, dyslipidemia, and SBP and DBP at admission, only DBP-NDR remained significantly associated with composite ASCVD, with an odds ratio of 1.029 (95% confidence interval 1.002-1.056, P=0.038). There were significant differences in the associations of SBP-NDR and DBP-NDR with composite ASCVD. Clinical conditions independently associated with SBP-NDR and DBP-NDR were also somewhat different. In a specific population group, DBP-NDR may be superior to SBP-NDR with respect to screening for ASCVD.
- Subjects :
- Adult
Male
medicine.medical_specialty
Ambulatory blood pressure
Physiology
Blood Pressure
White coat hypertension
030204 cardiovascular system & hematology
Prehypertension
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Humans
cardiovascular diseases
030212 general & internal medicine
Aged
business.industry
Odds ratio
Blood Pressure Monitoring, Ambulatory
Middle Aged
Atherosclerosis
medicine.disease
Confidence interval
Circadian Rhythm
Blood pressure
Hypertension
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Dyslipidemia
circulatory and respiratory physiology
Subjects
Details
- ISSN :
- 13484214 and 09169636
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Hypertension Research
- Accession number :
- edsair.doi.dedup.....b9f805a3a3e872decbe484490ce1aa17