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Impact of multi-micronutrient supplementation on lipidemia of children and adolescents
- Source :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP, Chakrabarti, Anirikh; Eiden, Michael; Morin-Rivron, Delphine; Christinat, Nicolas; Monteiro, Jacqueline P; Kaput, Jim; Masoodi, Mojgan (2020). Impact of multi-micronutrient supplementation on lipidemia of children and adolescents. Clinical nutrition, 39(7), pp. 2211-2219. Elsevier 10.1016/j.clnu.2019.09.010
- Publisher :
- CHURCHILL LIVINGSTONE
-
Abstract
- Background: Micronutrient supplementation has been extensively explored as a strategy to improve health and reduce risk of chronic diseases. Fat-soluble vitamins like A and E with their antioxidant properties and mechanistic interactions with lipoproteins, have potentially a key impact on lipid metabolism and lipidemia.<br />Objective: The impact of micronutrients on lipid metabolism requires further investigation including characterization of plasma lipidome following supplementation and any cause-effect on circulating lipids.<br />Design: In this study, we elucidate the effect and associations of a multi-micronutrient intervention in Brazilian children and teens with lipoprotein alterations and lipid metabolism.<br />Results: Our analysis suggests a combination of short and long-term impact of supplementation on lipid metabolism, potentially mediated primarily by alpha-tocopherol (vitamin E) and retinol (vitamin A). Among the lipid classes, levels of phospholipids, lysophospholipids, and cholesterol esters were impacted the most along with differential incorporation of stearic, palmitic, oleic and arachidonic acids. Integrated analysis with proteomic data suggested potential links to supplementation-mediated alterations in protein levels of phospholipases and pyruvate dehydrogenase kinase 1 (PDK1).<br />Conclusions: Associations between the observed differences in lipidemia, total triglyceride, and VLDL-cholesterol levels suggest that micronutrients may play a role in reducing these risk factors for cardiovascular disease in children. This would require further investigation. (C) 2019 The Author(s). Published by Elsevier Ltd.
- Subjects :
- Male
Proteomics
0301 basic medicine
Time Factors
vitamin-a-deficiency
medicine.medical_treatment
Cholesterol, VLDL
alpha-Tocopherol
efficacy
cardiovascular-disease
SISTEMA CARDIOVASCULAR
Critical Care and Intensive Care Medicine
chemistry.chemical_compound
0302 clinical medicine
prevention
610 Medicine & health
Child
Vitamin A
Nutrition and Dietetics
Age Factors
cardiovascular health
Lipidome
Micronutrient
vitamins
Lipids
Treatment Outcome
Female
lipids (amino acids, peptides, and proteins)
Brazil
Vitamin
lipidemia
medicine.medical_specialty
Adolescent
Hyperlipidemias
030209 endocrinology & metabolism
03 medical and health sciences
serum 25-hydroxyvitamin d
Internal medicine
medicine
Humans
cancer
Triglycerides
030109 nutrition & dietetics
Triglyceride
business.industry
Cholesterol
Vitamin E
Lipid metabolism
womens health
lipoproteins
Endocrinology
chemistry
micronutrients
tocotrienol-rich fraction
Dietary Supplements
lipidomics
business
metabolism
Biomarkers
Lipoprotein
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP, Chakrabarti, Anirikh; Eiden, Michael; Morin-Rivron, Delphine; Christinat, Nicolas; Monteiro, Jacqueline P; Kaput, Jim; Masoodi, Mojgan (2020). Impact of multi-micronutrient supplementation on lipidemia of children and adolescents. Clinical nutrition, 39(7), pp. 2211-2219. Elsevier 10.1016/j.clnu.2019.09.010 <http://dx.doi.org/10.1016/j.clnu.2019.09.010>
- Accession number :
- edsair.doi.dedup.....ba2a228f6d98092d6ca5c87810993bfe