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Abnormal nuchal translucency followed by normal microarray analysis is associated with placental pathologyârelated complications
- Source :
- Prenatal Diagnosis. 41:855-860
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Objective Identify placental pathology-related complications, labor and neonatal outcomes in pregnancies complicated by pathological nuchal translucency (NT) with normal microarray analysis. Methods A retrospective study in which all women with singleton pregnancy who demonstrated NT above 3 mm and a normal microarray analysis were matched to women with normal NT and a normal microarray analysis (2013-2019) in a single tertiary academic center. The following placental pathology-related parameters were measured: preeclampsia, oligohydramnios, suspected intrauterine growth restriction, abnormal Doppler studies or small for gestational age (SGA) neonates. The primary outcome was defined as a composite of complications related to placental pathology including preeclampsia and SGA neonate. Secondary outcomes were labor complications and neonatal morbidity. Results A total of 185 women were included in the study: of them, 47 presented an abnormal NT (study group) and 138 presented normal NT (controls). Groups did not significantly differ in baseline characteristics. Regarding primary outcome, all placental-related complications frequencies were higher in the study group, with a composite rate of 17.02% versus 6.52% in controls (p = 0.042%). Secondary outcomes did not differ between groups. Conclusions Abnormal NT measurement presented in pregnancies with normal fetal microarray analysis is associated with higher rates of placental-related complications.
- Subjects :
- Adult
0301 basic medicine
medicine.medical_specialty
Placenta
Intrauterine growth restriction
Oligohydramnios
030105 genetics & heredity
Preeclampsia
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Pregnancy
Humans
Medicine
Pathological
Genetics (clinical)
Retrospective Studies
Fetus
030219 obstetrics & reproductive medicine
business.industry
Obstetrics
Microarray analysis techniques
Infant, Newborn
Pregnancy Outcome
Obstetrics and Gynecology
Retrospective cohort study
Middle Aged
medicine.disease
Tissue Array Analysis
Small for gestational age
Female
Nuchal Translucency Measurement
business
Subjects
Details
- ISSN :
- 10970223 and 01973851
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Prenatal Diagnosis
- Accession number :
- edsair.doi.dedup.....ba2b7da71b6061ef7241961362f0b0be