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Statin use, high cholesterol and prostate cancer progression; results from HCaP‐NC
- Source :
- Allott, E H, Farnan, L, Steck, S E, Song, L, Arab, L, Su, L J, Fontham, E T H, Mohler, J L & Bensen, J T 2018, ' Statin use, high cholesterol and prostate cancer progression; results from HCaP-NC ', Prostate, vol. 78, no. 11, pp. 857-864 . https://doi.org/10.1002/pros.23644
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- BACKGROUND: Statin use is associated with lower advanced prostate cancer risk and reduced prostate cancer-specific mortality, but prior studies were conducted mainly in white men. We examined the effect of statin use on risk of prostate cancer progression in a population-based, minority-enriched cohort.METHODS: We used data from prostate cancer cases (45% African American) diagnosed between 2004 and 2007 who participated in the Health Care Access and Prostate Cancer Treatment in North Carolina cohort (HCaP-NC). We abstracted statin use at diagnosis. Men reported if they had ever been diagnosed with high cholesterol. Multivariable Cox proportional hazards analysis was used to examine associations between statin use and risk of prostate cancer progression (biochemical recurrence or secondary treatment), overall and by race. In secondary analysis, we examined the association between high cholesterol and risk of progression, overall, and by statin use.RESULTS: Of 669 men, 244 (36%) were statin users at diagnosis. During 3.8 years median follow-up, 138 men experienced prostate cancer progression. There was no association between statin use and risk of progression, either overall (HR 1.03; 95%CI 0.72-1.46) or stratified by race. High cholesterol was inversely associated with risk of progression, particularly among statin users (HR 0.43; 95%CI 0.20-0.94; p-interaction = 0.22) and in men with higher perceived access to care (HR 0.57; 95%CI 0.36-0.90; p-interaction = 0.03). Study limitations included a relatively small sample size, short follow-up, and lack of data regarding post diagnosis statin use.CONCLUSIONS: Statin use at diagnosis was not associated with prostate cancer progression in the population-based, minority-enriched HCaP-NC. Greater healthcare engagement, including actively controlling serum cholesterol, may be linked to better prostate cancer-specific outcomes.
- Subjects :
- Adult
Male
0301 basic medicine
Biochemical recurrence
Oncology
medicine.medical_specialty
Statin
medicine.drug_class
Urology
Black People
Health literacy
White People
High cholesterol
Cohort Studies
03 medical and health sciences
Prostate cancer
0302 clinical medicine
SDG 3 - Good Health and Well-being
Prostate
Internal medicine
North Carolina
medicine
Humans
Aged
business.industry
Proportional hazards model
Prostatic Neoplasms
Middle Aged
Louisiana
medicine.disease
Cholesterol
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Cohort
Disease Progression
Hydroxymethylglutaryl-CoA Reductase Inhibitors
business
Subjects
Details
- ISSN :
- 10970045 and 02704137
- Volume :
- 78
- Database :
- OpenAIRE
- Journal :
- The Prostate
- Accession number :
- edsair.doi.dedup.....ba387e4d9fd30274d532e9b0dd67545f