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A Novel Inflammation-Based Prognostic Score, the C-Reactive Protein/Albumin Ratio Predicts the Prognosis of Patients with Operable Esophageal Squamous Cell Carcinoma
- Source :
- PLoS ONE, PLoS ONE, Vol 10, Iss 9, p e0138657 (2015)
- Publication Year :
- 2015
-
Abstract
- Background Inflammation-based prognostic scores such as the neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), Glasgow prognostic score (GPS), and modified GPS (mGPS) have been reported to have prognostic value in patients with many types of cancer, including esophageal squamous cell carcinoma (ESCC). However, the role of the C-reactive protein/Albumin (CRP/Alb) ratio in ESCC has not yet been evaluated. Methods A total of 468 patients suffering from histologically proven ESCC were enrolled between January 2000 and July 2010. The GPS, mGPS, NLR, PLR and CRP/Alb ratios were tested together with established prognostic factors in univariate and multivariate Cox regression analyses of overall survival (OS). Results The optimal cutoff level for the CRP/Alb ratio was 0.50. The CRP/Alb ratio (continuous) had higher AUC values at 12 months (0.796), 24 months (0.805), and 36 months (0.815) than the NLR, GPS and mGPS. In univariate analysis, the 5-year OS rate for patients with a CRP/Alb ratio > 0.50 was 43.4%, while the rate for patients with a CRP/Alb ratio ≤ 0.50 was 17.7% (P < 0.0001). In multivariate analysis, patients with a CRP/Alb ratio > 0.50 had worse survival than patients with a CRP/Alb ratio ≤ 0.50 (HR: 2.44; 95% CI: 1.82–3.26; P < 0.0001). Conclusion In summary, to the best of our knowledge, this is the first study to identify the CRP/Alb ratio as a novel inflammation-based prognostic factor in a large group of ESCC patients. The prognostic value of the CRP/Alb ratio needs to be verified in prospective multicenter studies.
- Subjects :
- Blood Platelets
Male
medicine.medical_specialty
Pathology
Esophageal Neoplasms
Neutrophils
Lymphocyte
Serum albumin
lcsh:Medicine
Kaplan-Meier Estimate
Gastroenterology
Metastasis
Predictive Value of Tests
Internal medicine
medicine
Carcinoma
Humans
Lymphocytes
lcsh:Science
Diagnostic Techniques and Procedures
Serum Albumin
Proportional Hazards Models
Inflammation
Multidisciplinary
biology
business.industry
lcsh:R
C-reactive protein
Albumin
Cancer
Middle Aged
medicine.disease
Prognosis
digestive system diseases
medicine.anatomical_structure
C-Reactive Protein
Predictive value of tests
Multivariate Analysis
biology.protein
Carcinoma, Squamous Cell
lcsh:Q
Female
business
Research Article
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 10
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....ba4b9763d42a3f8871b32b6e6f43f7c0