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Plasma cell leukemia with plasmablastic morphology in a dog
- Source :
- J Vet Diagn Invest
- Publication Year :
- 2019
- Publisher :
- SAGE Publications, 2019.
-
Abstract
- A 5-y-old female Golden Retriever was presented with a 2-wk history of hyporexia, vomiting, diarrhea, lethargy, weight loss, polyuria, and polydipsia. Clinical examination and ultrasonography revealed multiple organ enlargement with gallbladder and kidney nodules suggestive of disseminated neoplasia. Hematologic and biochemical analyses revealed pancytopenia, hypercalcemia, and monoclonal IgA gammopathy suspicious for a plasma cell neoplasm. Bone marrow and blood smear examination revealed neoplastic atypical cells highly suggestive of lymphoid origin. Autopsy confirmed the presence of homogeneous white masses and multifocal pale infiltrates in the spleen, kidney, small intestine, gallbladder, and urinary tract. Histologic features were consistent with a multicentric atypical plasma cell tumor. Tumor cells were negative for CD204, IBA-1, E-cadherin, CD3, CD5, CD79a, CD20, and PAX5, and positive for MUM1, consistent with plasma cell origin. The presence of > 20% of circulating blastic plasma cells was consistent with primary plasma cell leukemia with plasmablastic morphology, a disease rarely described in veterinary medicine.
- Subjects :
- Pathology
medicine.medical_specialty
040301 veterinary sciences
Plasma cell
Leukemia, Plasma Cell
0403 veterinary science
03 medical and health sciences
Dogs
Fatal Outcome
0302 clinical medicine
hemic and lymphatic diseases
Gammopathy
medicine
Animals
Dog Diseases
Plasma cell leukemia
CD20
General Veterinary
biology
business.industry
04 agricultural and veterinary sciences
Plasma cell neoplasm
medicine.disease
Pancytopenia
medicine.anatomical_structure
biology.protein
Female
Bone marrow
CD5
Brief Communications
business
Plasmacytoma
030215 immunology
Subjects
Details
- ISSN :
- 19434936 and 10406387
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Journal of Veterinary Diagnostic Investigation
- Accession number :
- edsair.doi.dedup.....ba5096b080657a50fa4f207e329d34c5