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Proof of concept for the inhibition of foot-and-mouth disease virus replication by the anti-viral drug 2'-C-methylcytidine in severe combined immunodeficient mice
- Source :
- Transboundary and Emerging Diseases
- Publication Year :
- 2013
-
Abstract
- Summary Recent European contingency plans envisage emergency vaccination as an animal-friendly control strategy for foot-and-mouth disease (FMD). Anti-viral drugs may be used as an alternative or complementary measure. We here demonstrate that the nucleoside analogue 2′-C-methylcytidine (2′CMC) protects severe combined immunodeficient (SCID) mice against lethal FMD virus infection. In brief, SCID mice were inoculated with serotype A FMD virus and treated for five consecutive days with 2′CMC. All 15 treated mice remained healthy until the end of the study at 14 days post-infection (dpi). At that time, viral RNA was no longer detected in 13 of 15 treated mice. All eight untreated mice suffered from an acute generalized disease and were euthanized for ethical reasons on average at 4 dpi. These results illustrate the potential of small molecules to control FMD.
- Subjects :
- Serotype
Drug
media_common.quotation_subject
Disease
Cytidine
Mice, SCID
Biology
Antiviral Agents
03 medical and health sciences
Mice
medicine
Animals
030304 developmental biology
media_common
0303 health sciences
General Veterinary
General Immunology and Microbiology
Nucleoside analogue
Foot-and-mouth disease
030306 microbiology
General Medicine
biology.organism_classification
medicine.disease
Virology
3. Good health
Vaccination
Disease Models, Animal
Viral replication
Foot-and-Mouth Disease Virus
Foot-and-Mouth Disease
Immunology
RNA, Viral
Foot-and-mouth disease virus
medicine.drug
Subjects
Details
- ISSN :
- 18651682
- Volume :
- 61
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Transboundary and emerging diseases
- Accession number :
- edsair.doi.dedup.....ba7ae3cf954863ea26c71ccd905c79d8