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A novel flavonoid and other constituents from Rubus rosifolius S.Vidal (Rosaceae)
- Publication Year :
- 2023
- Publisher :
- Taylor & Francis, 2023.
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Abstract
- Various reports revealed that chemical constituents from many species of Rubus exhibit diverse biological activities. In this study, a novel flavonoid with a 2-(phenanthren-9-yl)-4H-chromen-4-one structure (1), a 5-phenylthiophene-2-carbaldehyde derivative (5) first isolated from a natural source, together with five known compounds including three polyketides (2–4) and two sesquiterpenoids (6–7) were isolated from a traditional Chinese medicine Rubus rosifolius S.Vidal (Rosaceae). The structures of new compounds were elucidated by detailed spectroscopic analysis including NMR and X-ray single-crystal diffraction. The bioassays results indicated that, compound 1 displayed significant cytotoxicity against human colon cancer cell line HCT116 with IC50 value of 8.6 ± 1.9 μM, and compound 5 exhibited moderate cytotoxicity against human breast cancer cell line MDA-MB-435 with IC50 value of 24.1 ± 0.8 μM.
- Subjects :
- Organic Chemistry
Plant Science
Biochemistry
Analytical Chemistry
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....ba7be8fb5635325919675f0a282ce340
- Full Text :
- https://doi.org/10.6084/m9.figshare.21971686