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A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection
- Source :
- Scientific Reports
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- One of the largest single sources of epilepsy in the world is produced as a neurological sequela in survivors of cerebral malaria. Nevertheless, the pathophysiological mechanisms of such epileptogenesis remain unknown and no adjunctive therapy during cerebral malaria has been shown to reduce the rate of subsequent epilepsy. There is no existing animal model of postmalarial epilepsy. In this technical report we demonstrate the first such animal models. These models were created from multiple mouse and parasite strain combinations, so that the epilepsy observed retained universality with respect to genetic background. We also discovered spontaneous sudden unexpected death in epilepsy (SUDEP) in two of our strain combinations. These models offer a platform to enable new preclinical research into mechanisms and prevention of epilepsy and SUDEP.
- Subjects :
- Male
0301 basic medicine
Plasmodium berghei
Malaria, Cerebral
Electroencephalography
Bioinformatics
Epileptogenesis
Article
Death, Sudden
Mice
03 medical and health sciences
Epilepsy
0302 clinical medicine
medicine
Animals
Survival analysis
Multidisciplinary
biology
medicine.diagnostic_test
business.industry
biology.organism_classification
medicine.disease
Survival Analysis
Disease Models, Animal
030104 developmental biology
Cerebral Malaria
Murine model
business
030217 neurology & neurosurgery
Malaria
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....ba9f3735fea89d66ab5f2153b8e036a1