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Anthropometric and Metabolic Risk Factors for ESRD Are Disease-Specific: Results from a Large Population-Based Cohort Study in Austria
Anthropometric and Metabolic Risk Factors for ESRD Are Disease-Specific: Results from a Large Population-Based Cohort Study in Austria
- Source :
- PLoS ONE, PLoS ONE, Vol 11, Iss 8, p e0161376 (2016)
- Publication Year :
- 2016
-
Abstract
- Background Anthropometric and metabolic risk factors for all-cause end-stage renal disease (ESRD) may vary in their impact depending on the specific primary renal disease. Methods In this Austrian population-based prospective cohort study (n = 185,341; 53.9% women) the following data were collected between 1985 and 2005: age, sex, body mass index (BMI), fasting blood glucose (FBG) from 1988, blood pressure, total cholesterol (TC), triglycerides (TG), gamma-glutamyl transferase (GGT) and smoking status. These data were merged with the Austrian Dialysis and Transplant Registry to identify ESRD patients. Cox proportional hazards models were applied to calculate hazard ratios (HR) for all-cause ESRD as well as for cause-specific ESRD due to the following primary renal diseases: autosomal dominant polycystic kidney disease (ADPKD), vascular nephropathy (VN), diabetic nephropathy (DN) and other diseases (OD). Results During a mean follow-up of 17.5 years 403 participants developed ESRD (ADPKD 36, VN 97, DN 86, and OD 184). All parameters except TG and GGT were significantly associated with all-cause ESRD risk. Particular cause-specific ESRD risk factor patterns were found: for ADPKD increased risk from hypertension (HR 11.55); for VN from smoking (HR 1.81), hypertension (HR 2.37), TG (≥5.70 vs.
- Subjects :
- Blood Glucose
Male
Pediatrics
Physiology
030232 urology & nephrology
lcsh:Medicine
Blood Pressure
urologic and male genital diseases
Gastroenterology
Vascular Medicine
Body Mass Index
Diabetic nephropathy
0302 clinical medicine
Endocrinology
Risk Factors
Chronic Kidney Disease
Medicine and Health Sciences
Diabetic Nephropathies
030212 general & internal medicine
Prospective Studies
Prospective cohort study
lcsh:Science
education.field_of_study
Polycystic Kidney Diseases
Multidisciplinary
Smoking
gamma-Glutamyltransferase
Middle Aged
Cholesterol
Physiological Parameters
Nephrology
Austria
Hypertension
Female
Research Article
Adult
medicine.medical_specialty
Endocrine Disorders
Population
Autosomal dominant polycystic kidney disease
Nephropathy
03 medical and health sciences
Internal medicine
Diabetes mellitus
medicine
Diabetes Mellitus
Renal Diseases
Humans
Obesity
Risk factor
education
Triglycerides
Proportional Hazards Models
business.industry
lcsh:R
Body Weight
Health Risk Analysis
Biology and Life Sciences
medicine.disease
Health Care
Metabolic Disorders
Kidney Failure, Chronic
lcsh:Q
business
Body mass index
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 11
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....bad0529c74365f697d8f5c7967293751