Back to Search Start Over

An Investigation of Popping During Radiofrequency Ablation After Lenvatinib Administration for Hepatocellular Carcinoma

Authors :
TORU ISHIKAWA
IORI HASEGAWA
HIROSHI HIROSAWA
TSUBASA HONMOU
NOBUYUKI SAKAI
TAKANORI IGARASHI
SHUN YAMAZAKI
TAKAMASA KOBAYASHI
TOSHIFUMI SATO
AKITO IWANAGA
TOMOE SANO
JUNJI YOKOYAMA
TERASU HONMA
Source :
In Vivo
Publication Year :
2023
Publisher :
Anticancer Research USA Inc., 2023.

Abstract

Background/Aim: Lenvatinib is available as a molecular target agent for hepatocellular carcinoma (HCC). In this study, we investigated the popping phenomena in patients with HCC who underwent radiofrequency ablation (RFA) after taking lenvatinib. Patients and Methods: Fifty-nine patients with HCC between 21-30 mm in diameter and no history of systemic treatment were enrolled in the study. The patients underwent RFA using a VIVA RFA SYSTEM with an ablation tip of 30 mm in length. For the initial lenvatinib administration, 16 patients had an adequate course of treatment and were treated with RFA as add-on therapy (combination group). The other 43 patients were treated by RFA monotherapy (monotherapy group). The popping frequency during RFA was recorded and compared. Results: Popping frequency in the combination group (RFA combined with lenvatinib) was significantly higher than that in the monotherapy group. There was no significant difference between the combination group and the monotherapy group in ablation time, maximum output level, tumour temperature after ablation, or initial resistance value. Conclusion: Popping frequency was significantly higher in the combination group. It is possible that the intra-tumour temperature increased rapidly during RFA in the combination group due to the inhibitory effect of lenvatinib on tumour angiogenesis, leading to the occurrence of popping. Further studies are needed to investigate popping after RFA, and precise protocols need to be developed.

Details

ISSN :
17917549 and 0258851X
Volume :
37
Database :
OpenAIRE
Journal :
In Vivo
Accession number :
edsair.doi.dedup.....bada7e7b436db754df61a49b4ddc2500
Full Text :
https://doi.org/10.21873/invivo.13150