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Diversity of Nuclear Lamin A/C Action as a Key to Tissue-Specific Regulation of Cellular Identity in Health and Disease
- Source :
- Frontiers in Cell and Developmental Biology, Frontiers in Cell and Developmental Biology, Vol 9 (2021)
- Publication Year :
- 2021
-
Abstract
- A-type lamins are the main structural components of the nucleus, which are mainly localized at the nucleus periphery. First of all, A-type lamins, together with B-type lamins and proteins of the inner nuclear membrane, form a stiff structure—the nuclear lamina. Besides maintaining the nucleus cell shape, A-type lamins play a critical role in many cellular events, such as gene transcription and epigenetic regulation. Nowadays it is clear that lamins play a very important role in determining cell fate decisions. Various mutations in genes encoding A-type lamins lead to damages of different types of tissues in humans, collectively known as laminopathies, and it is clear that A-type lamins are involved in the regulation of cell differentiation and stemness. However, the mechanisms of this regulation remain unclear. In this review, we discuss how A-type lamins can execute their regulatory role in determining the differentiation status of a cell. We have summarized recent data focused on lamin A/C action mechanisms in regulation of cell differentiation and identity development of stem cells of different origin. We also discuss how this knowledge can promote further research toward a deeper understanding of the role of lamin A/C mutations in laminopathies.
- Subjects :
- congenital, hereditary, and neonatal diseases and abnormalities
animal structures
QH301-705.5
Cellular differentiation
Cell
Review
Biology
Cell fate determination
Cell and Developmental Biology
medicine
Inner membrane
LADs
Epigenetics
Biology (General)
LMNA gene
lamin A/C
Regulation of gene expression
integumentary system
laminopathies
Cell Biology
Cell biology
cell differentiation
medicine.anatomical_structure
embryonic structures
Nuclear lamina
regulation of gene expression
Lamin
Developmental Biology
chromatin organization
Subjects
Details
- ISSN :
- 2296634X
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Frontiers in cell and developmental biology
- Accession number :
- edsair.doi.dedup.....badfc2ce4b2fcfcf6431494488ad0cc1