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Curcumin activation of nuclear factor E2-related factor 2 gene (Nrf2): Prophylactic and therapeutic effect in nonalcoholic steatohepatitis (NASH)
- Source :
- Life Sciences. 285:119983
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Backgrounds Modern dietary habits have been associated with Nonalcoholic Steatohepatitis (NASH). Curcumin is a natural herbal found to suppress cellular oxidative states and could be beneficial in NASH. This study investigates the effect of curcumin in an animal model of NASH. Materials and methods Fifty rats were allocated into five groups. Control, High Fat Diet (HFD), curcumin prophylactic (CP) and therapeutic (CT) groups. HFD regimen was given for 16 weeks. Curcumin was given along with HFD (prophylactic) or after establishment of the model for two weeks (therapeutic). Livers and blood samples were harvested for histological, biochemical, and molecular studies. Key findings Livers from HFD groups showed vascular, inflammatory, cellular degenerative and fibrotic changes. The hepatic damage was reflected by the increased serum liver enzymes. HFD groups showed excessive fibrotic change. Interestingly, curcumin administration as prophylactic or therapeutic significantly preserved and/or restored liver structure. This was evidenced by the normalization of the liver enzymes, preservation and/or reversibility of cellular changes and the decrease of the stage of fibrosis. Nuclear factor E2-related factor 2 gene (Nrf2) expression showed no changes in the HFD groups, however it showed upregulation in curcumin treated groups. Thus, the protective and therapeutic effect of curcumin could be induced through upregulation of the Nrf2 gene. Curcumin has a beneficial prophylactic and therapeutic effect that could hinder the development and/or treat NASH in susceptible livers. Significance Curcumin has a beneficial prophylactic and therapeutic effect that could hinder the development and/or treat NASH in susceptible livers.
- Subjects :
- Male
Nonalcoholic steatohepatitis
Curcumin
NF-E2-Related Factor 2
Oxidative phosphorylation
Pharmacology
Diet, High-Fat
General Biochemistry, Genetics and Molecular Biology
Rats, Sprague-Dawley
chemistry.chemical_compound
Animal model
Downregulation and upregulation
Non-alcoholic Fatty Liver Disease
Fibrosis
Animals
Medicine
General Pharmacology, Toxicology and Pharmaceutics
Gene
business.industry
Body Weight
Therapeutic effect
nutritional and metabolic diseases
General Medicine
medicine.disease
Rats
Microscopy, Electron
Liver
chemistry
Collagen
business
Subjects
Details
- ISSN :
- 00243205
- Volume :
- 285
- Database :
- OpenAIRE
- Journal :
- Life Sciences
- Accession number :
- edsair.doi.dedup.....bb064f6e64b329f3d43302cec3f45229