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Role of Adiponectin and Brain Derived Neurotrophic Factor in Metabolic Regulation Involved in Adiposity and Body Fat Browning
- Source :
- Journal of Clinical Medicine, Volume 10, Issue 1, Journal of Clinical Medicine, Vol 10, Iss 56, p 56 (2021)
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Obesity, characterized by excessive fat mass, has been emerging as a major global epidemic and contributes to the increased risk of morbidity around the world. Thus, the necessity to find effective therapy and specific regulatory mechanisms is increasing for controlling obesity. Lately, many researchers have been interested in the linkage between obesity and adipokines/myokines, particularly adiponectin and brain-derived neurotrophic factor (BDNF). However, the role of adiponectin and BDNF in adiposity has not been clearly defined yet. We examined the association of adiposity with adiponectin and BDNF through human study (observational study) with Korean women and in vitro experiments. In the human study, we found a negative relationship between adiposity and circulating adiponectins but irregular patterns in the relationship between adiposity and circulating BDNFs. In the in vitro study using 3T3-L1 adipocytes, adiponectin treatment strongly promoted adipocyte differentiation and the fat browning process, whereas BDNF treatment attenuated adipocyte differentiation and the fat browning process in differentiated adipocytes. Our results demonstrate that adiponectin and BDNF play an important role in regulating fat mass and the expression of fat-browning markers in different ways, and also suggest that circulating adiponectin may be used as an important monitoring index for obesity status.
- Subjects :
- 0301 basic medicine
obesity
medicine.medical_specialty
lcsh:Medicine
Adipokine
adipocyte
Article
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Neurotrophic factors
Internal medicine
Adipocyte
Myokine
medicine
Browning
Brain-derived neurotrophic factor
adiponectin
Adiponectin
business.industry
lcsh:R
brain-derived neurotrophic factor
fat browning
General Medicine
medicine.disease
Obesity
030104 developmental biology
Endocrinology
chemistry
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 20770383
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....bb0cf5cda660966ed8e2959b4fdc1deb