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Effects of time-restricted feeding on body weight and metabolism. A systematic review and meta-analysis
- Publication Year :
- 2019
-
Abstract
- Restriction in meal timing has emerged as a promising dietary approach for the management of obesity and dysmetabolic diseases. The present systematic review and meta-analysis summarized the most recent evidence on the effect of time-restricted feeding (TRF) on weight-loss and cardiometabolic variables in comparison with unrestricted-time regimens. Studies involving TRF regimen were systematically searched up to January 2019. Effect size was expressed as weighted mean difference (WMD) and 95% confidence intervals (CI). A total of 11 studies, 5 randomized controlled trials and 6 observational, were included. All selected studies had a control group without time restriction; hours of fasting ranged from 12-h until 20-h and study duration from 4 to 8-weeks. Most studies involved the Ramadan fasting. TRF determined a greater weight-loss than control regimens (11 studies, n = 485 subjects) (WMD: −1.07 kg, 95%CI: −1.74 to −0.40; p = 0.002; I2 = 56.2%), unrelated to study design. The subgroup analysis showed an inverse association between TRF and fat free mass in observational studies (WMD: −1.33 kg, 95%CI: −2.55 to −0.11; p = 0.03; I2 = 0%). An overall significant reduction in fasting glucose concentrations was observed with TRF regimens (7 studies, n = 363 subjects) (WMD: −1.71 mg/dL, 95%CI: −3.20 to −0.21; p = 0.03; I2 = 0%), above all in trials (WMD:-2.45 mg/dL, 95%CI: −4.72 to −0.17; p = 0.03; I2 = 0%). No between-group differences in the other variables were found. TRF regimens achieved a superior effect in promoting weight-loss and reducing fasting glucose compared to approaches with unrestricted time in meal consumption. However, long-term and well-designed trials are needed to draw definitive conclusions.
- Subjects :
- Adult
Blood Glucose
Male
medicine.medical_specialty
Weight loss
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
030209 endocrinology & metabolism
Subgroup analysis
Management of obesity
law.invention
03 medical and health sciences
Young Adult
0302 clinical medicine
Endocrinology
Randomized controlled trial
law
Diabetes mellitus
Internal medicine
Time restricted feeding
medicine
Humans
Obesity
Observational studies
Aged
Randomized Controlled Trials as Topic
Meal
Fasting glucose
Nutrition and Dietetics
business.industry
Body Weight
Fasting
Middle Aged
medicine.disease
Confidence interval
Randomized controlled trials
Observational Studies as Topic
Regimen
Meta-analysis
Female
Observational study
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....bb0d6b1535b99b30d37277cd0886b202