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Elevated energy intake is correlated with hyperresponsivity in attentional, gustatory, and reward brain regions while anticipating palatable food receipt
Elevated energy intake is correlated with hyperresponsivity in attentional, gustatory, and reward brain regions while anticipating palatable food receipt
- Source :
- The American Journal of Clinical Nutrition. 97:1188-1194
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Background: Obese compared with lean individuals show greater attention-, gustatory-, and reward-region responsivity to food cues but reduced reward-region responsivity during food intake. However, to our knowledge, research has not tested whether an objectively measured caloric intake is positively associated with neural responsivity independent of excess adipose tissue. Objective: We tested the hypothesis that objectively measured energy intake, which accounts for basal needs and the percentage of body fat, correlates positively with the neural response to anticipated palatable food intake but negatively with a response to food intake in healthy-weight adolescents. Design: Participants (n = 155; mean ± SD age: 15.9 ± 1.1 y) completed functional magnetic resonance imaging scans while anticipating and receiving palatable food compared with a tasteless solution, a doubly labeled water assessment of energy intake, and assessments of resting metabolic rate and body composition. Results: Energy intake correlated positively with activation in the lateral visual and anterior cingulate cortices (visual processing and attention), frontal operculum (primary gustatory cortex) when anticipating palatable food, and greater striatal activation when anticipating palatable food in a more-sensitive region of interest analysis. Energy intake was not significantly related to neural responsivity during palatable food intake. Conclusions: Results indicate that objectively measured energy intake that accounts for basal needs and adipose tissue correlates positively with activity in attentional, gustatory, and reward regions when anticipating palatable food. Although hyperresponsivity of these regions may increase risk of overeating, it is unclear whether this is an initial vulnerability factor or a result of previous overeating. This trial was registered at clinicaltrials.gov as {"type":"clinical-trial","attrs":{"text":"NCT01807572","term_id":"NCT01807572"}}NCT01807572.
- Subjects :
- Male
medicine.medical_specialty
Taste
Adolescent
Obesity and Eating Disorders
Medicine (miscellaneous)
Doubly labeled water
Hyperphagia
Body Mass Index
Eating
Reward
Internal medicine
medicine
Humans
Attention
Prospective Studies
Overeating
Nutrition and Dietetics
medicine.diagnostic_test
business.industry
Anticipation, Psychological
medicine.disease
Magnetic Resonance Imaging
Obesity
Corpus Striatum
Oxygen
Endocrinology
Adipose Tissue
Basal (medicine)
Basal metabolic rate
Body Composition
Regression Analysis
Female
Cues
Energy Intake
Gustatory cortex
Functional magnetic resonance imaging
business
psychological phenomena and processes
Subjects
Details
- ISSN :
- 00029165
- Volume :
- 97
- Database :
- OpenAIRE
- Journal :
- The American Journal of Clinical Nutrition
- Accession number :
- edsair.doi.dedup.....bb4623f69e5627c886eac17d7ea29c4f
- Full Text :
- https://doi.org/10.3945/ajcn.112.055285