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Antecedent infections in Guillain-Barré syndrome patients from south India
- Source :
- Europe PubMed Central, ORCID, Microsoft Academic Graph
- Publication Year :
- 2021
-
Abstract
- Guillain-Barre syndrome (GBS) is the commonest post-infectious inflammatory peripheral neuropathy with undiscerned aetiology. The commonly reported antecedent infections implicated in India include Campylobacter jejuni, chikungunya, dengue, and Japanese encephalitis (JE). In this study from south India, we investigated the role of these four agents in triggering GBS. This case-control study was performed on 150 treatment-naive patients with GBS and 150 age and sex-matched controls from the same community. IgM immunoreactivity for C. jejuni, chikungunya, and dengue was detected by enzyme-linked immunosorbent assay (ELISA) in serum of patients with GBS and control subjects. Immunoreactivity against JE was detected in serum as well as cerebrospinal fluid (CSF) from patients (n = 150) and orthopaedic control (n = 45) subjects. The immunoreactivity against infections was compared between demyelinating and axonal subtypes of GBS. Overall, 119/150 patients with GBS had serological evidence of antecedent infection. Amongst those with evidence of antecedent infection, 24 (16%), 8 (5%), and 9 (6%) patients were exclusively immunoreactive to chikungunya, JE, and C. jejuni, respectively. In the remaining patients (78/119), immunoreactivity to multiple pathogens was noted. Immunoreactivity to C. jejuni infection was found in 32% of GBS patients compared to 2.7% controls (P
- Subjects :
- medicine.medical_specialty
medicine.disease_cause
Guillain-Barre Syndrome
Campylobacter jejuni
Gastroenterology
Virus
Dengue fever
Dengue
Internal medicine
medicine
Humans
Chikungunya
biology
Guillain-Barre syndrome
business.industry
General Neuroscience
Japanese encephalitis
bacterial infections and mycoses
medicine.disease
biology.organism_classification
Peripheral neuropathy
Immunoglobulin M
Case-Control Studies
Etiology
Chikungunya Fever
Neurology (clinical)
business
Subjects
Details
- ISSN :
- 15298027
- Volume :
- 26
- Issue :
- 1529-8027
- Database :
- OpenAIRE
- Journal :
- Journal of the peripheral nervous system : JPNSREFERENCES
- Accession number :
- edsair.doi.dedup.....bb65dbbf66045c1086d21a98f080b058