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Extent of Coronary Artery Disease in Patients With Stenotic Bicuspid Versus Tricuspid Aortic Valves
- Source :
- Journal of the American Heart Association, 10(12). Wiley-Blackwell, Journal of the American Heart Association, 10(12):e020080. Wiley-Blackwell, Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, 10(12). WILEY, Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
- Publication Year :
- 2021
-
Abstract
- Background Bicuspid aortic valve (BAV) is the most common congenital cardiac malformation, which is often complicated by aortic valve stenosis (AoS). In tricuspid aortic valve (TAV), AoS strongly associates with coronary artery disease (CAD) with common pathophysiological factors. Yet, it remains unclear whether AoS in patients with BAV is also associated with CAD. This study investigated the association between the aortic valve morphological features and the extent of CAD. Methods and Results A single‐center study was performed, including all patients who underwent an aortic valve replacement attributable to AoS between 2006 and 2019. Coronary sclerosis was graded on preoperative coronary angiographies using the coronary artery greater even than scoring method, which divides the coronaries in 28 segments and scores nonobstructive (20%–49% sclerosis) and obstructive coronary sclerosis (>49% sclerosis) in each segment. Multivariate analyses were performed, controlling for age, sex, and CAD risk factors. A total of 1296 patients (931 TAV and 365 BAV) were included, resulting in 548 matched patients. Patients with TAV exhibited more CAD risk factors (odds ratio [OR], 2.66; 95% CI, 1.79–3.96; P P P P Conclusions Patients with BAV who are undergoing surgery for AoS carry a lower cardiovascular risk profile, correlating with less coronary sclerosis and a lower incidence of concomitant coronary revascularization compared with patients with TAV.
- Subjects :
- Aortic valve
Male
medicine.medical_specialty
bicuspid aortic valve
Aortic Valve Stenosis/diagnostic imaging
aortic valve stenosis
030204 cardiovascular system & hematology
Coronary Angiography
Severity of Illness Index
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Bicuspid aortic valve
Bicuspid Aortic Valve Disease
Aortic valve replacement
Bicuspid Aortic Valve Disease/diagnostic imaging
Risk Factors
Cardiovascular Disease
Internal medicine
Prevalence
Coronary Heart Disease
Medicine
Humans
aortic valve replacement
030212 general & internal medicine
Original Research
Aged
Netherlands
Retrospective Studies
Heart Valve Prosthesis Implantation
business.industry
Odds ratio
Middle Aged
medicine.disease
medicine.anatomical_structure
Treatment Outcome
Concomitant
Aortic valve stenosis
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
coronary artery disease
Artery
Coronary Artery Disease/diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 20479980
- Volume :
- 10
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of the American Heart Association
- Accession number :
- edsair.doi.dedup.....bb6b0eaacefd86ee90311db816ae7b0f