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Outcome and Treatment of Nocardiosis After Solid Organ Transplantation: New Insights From a European Study
- Source :
- Clinical Infectious Diseases, Clinical Infectious Diseases, Oxford University Press (OUP), 2017, 64 (10), pp.1396-1405. ⟨10.1093/cid/cix124⟩, Clinical Infectious Diseases, Vol. 64, No 10 (2017) pp. 1396-1405, Lebeaux, David; Freund, Romain; van Delden, Christian; Guillot, Hélène; Marbus, Sierk D; Matignon, Marie; Van Wijngaerden, Eric; Douvry, Benoit; De Greef, Julien; Vuotto, Fanny; Tricot, Leïla; Fernández-Ruiz, Mario; Dantal, Jacques; Hirzel, Cédric; Jais, Jean-Philippe; Rodriguez-Nava, Veronica; Jacobs, Frédérique; Lortholary, Olivier; Coussement, Julien (2017). Outcome and treatment of nocardiosis after solid organ transplantation: new insights from a European study. Clinical infectious diseases, 64(10), pp. 1396-1405. Oxford University Press 10.1093/cid/cix124
- Publication Year :
- 2017
- Publisher :
- HAL CCSD, 2017.
-
Abstract
- Background Solid organ transplant (SOT) recipients are at risk of nocardiosis, a rare opportunistic bacterial infection, but prognosis and outcome of these patients are poorly defined. Our objectives were to identify factors associated with one-year mortality after nocardiosis and describe the outcome of patients receiving short-course antibiotics (≤120 days). Methods We analyzed data from a multicenter European case-control study that included 117 SOT recipients with nocardiosis diagnosed between 2000 and 2014. Factors associated with one-year all-cause mortality were identified using multivariable conditional logistic regression. Results One-year mortality was 10-fold higher in patients with nocardiosis (16.2%, 19/117) than in control transplant recipients (1.3%, 3/233, p
- Subjects :
- 0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
medicine.drug_class
[SDV]Life Sciences [q-bio]
030106 microbiology
Antibiotics
Improved survival
610 Medicine & health
Nocardia
03 medical and health sciences
Internal medicine
medicine
In patient
opportunistic infections
ddc:617
business.industry
Nocardiosis
organ transplantation
Odds ratio
medicine.disease
mortality
Confidence interval
3. Good health
Surgery
Infectious Diseases
Conditional logistic regression
prognosis
Solid organ transplantation
business
Subjects
Details
- Language :
- English
- ISSN :
- 10584838 and 15376591
- Database :
- OpenAIRE
- Journal :
- Clinical Infectious Diseases, Clinical Infectious Diseases, Oxford University Press (OUP), 2017, 64 (10), pp.1396-1405. ⟨10.1093/cid/cix124⟩, Clinical Infectious Diseases, Vol. 64, No 10 (2017) pp. 1396-1405, Lebeaux, David; Freund, Romain; van Delden, Christian; Guillot, Hélène; Marbus, Sierk D; Matignon, Marie; Van Wijngaerden, Eric; Douvry, Benoit; De Greef, Julien; Vuotto, Fanny; Tricot, Leïla; Fernández-Ruiz, Mario; Dantal, Jacques; Hirzel, Cédric; Jais, Jean-Philippe; Rodriguez-Nava, Veronica; Jacobs, Frédérique; Lortholary, Olivier; Coussement, Julien (2017). Outcome and treatment of nocardiosis after solid organ transplantation: new insights from a European study. Clinical infectious diseases, 64(10), pp. 1396-1405. Oxford University Press 10.1093/cid/cix124 <http://dx.doi.org/10.1093/cid/cix124>, Clinical Infectious Diseases, Vol. 64, no. 10, p. 1396-1405 (2017)
- Accession number :
- edsair.doi.dedup.....bb8923c179ac7bd557d07bbac1b060aa