Back to Search
Start Over
Repetitive closed-head impact model of engineered rotational acceleration (CHIMERA) injury in rats increases impulsivity, decreases dopaminergic innervation in the olfactory tubercle and generates white matter inflammation, tau phosphorylation and degeneration
- Source :
- Experimental Neurology. 317:87-99
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Traumatic brain injury (TBI) affects at least 3 M people annually. In humans, repetitive mild TBI (rmTBI) can lead to increased impulsivity and may be associated with chronic traumatic encephalopathy. To better understand the relationship between repetitive TBI (rTBI), impulsivity and neuropathology, we used CHIMERA (Closed-Head Injury Model of Engineered Rotational Acceleration) to deliver five TBIs to rats, which were continuously assessed for trait impulsivity using the delay discounting task and for neuropathology at endpoint. Compared to sham controls, rats with rTBI displayed progressive impairment in impulsive choice. Histological analyses revealed reduced dopaminergic innervation from the ventral tegmental area to the olfactory tubercle, consistent with altered impulsivity neurocircuitry. Consistent with diffuse axonal injury generated by CHIMERA, white matter inflammation, tau immunoreactivity and degeneration were observed in the optic tract and corpus callosum. Finally, pronounced grey matter microgliosis was observed in the olfactory tubercle. Our results provide insight into the mechanisms by which rTBI leads to post-traumatic psychiatric-like symptoms in a novel rat TBI platform.
- Subjects :
- Male
0301 basic medicine
Traumatic brain injury
tau Proteins
Grey matter
Impulsivity
Choice Behavior
Corpus Callosum
White matter
03 medical and health sciences
0302 clinical medicine
Reward
Developmental Neuroscience
Head Injuries, Closed
medicine
Animals
Rats, Long-Evans
Gliosis
Phosphorylation
Inflammation
business.industry
Dopaminergic Neurons
Olfactory tubercle
Olfactory Tubercle
Diffuse axonal injury
Neurodegenerative Diseases
medicine.disease
White Matter
Axons
Rats
Ventral tegmental area
Disease Models, Animal
Chronic traumatic encephalopathy
030104 developmental biology
medicine.anatomical_structure
Tauopathies
Neurology
medicine.symptom
business
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 00144886
- Volume :
- 317
- Database :
- OpenAIRE
- Journal :
- Experimental Neurology
- Accession number :
- edsair.doi.dedup.....bba65955eacab6912a36f189333a644e