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Hydrogen sulfide and hepatic lipid metabolism – a critical pairing for liver health
- Source :
- Br J Pharmacol
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Hydrogen sulfide (H(2)S) is the most recently recognized gasotransmitter, influencing a wide range of physiological processes. As a critical regulator of metabolism, H(2)S has been suggested to be involved in the pathology of many diseases, particularly obesity, diabetes and cardiovascular disorders. Its involvement in liver health has been brought to light more recently, particularly through knockout animal models, which show severe hepatic lipid accumulation upon ablation of H(2)S metabolic pathways. A complex relationship between H(2)S and lipid metabolism in the liver is emerging, which has significant implications for liver disease establishment and/or progression, regardless of the disease‐causing agent. In this review, we discuss the critical importance of H(2)S in hepatic lipid metabolism. We then describe the animal models so far related with H(2)S and lipid‐associated liver disease, as well as H(2)S‐based treatments available. Finally, we highlight important considerations for future studies and identify areas in which much still remains to be determined. LINKED ARTICLES: This article is part of a themed section on Hydrogen Sulfide in Biology & Medicine. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.4/issuetoc
- Subjects :
- 0301 basic medicine
Hydrogen sulfide
Bioinformatics
03 medical and health sciences
chemistry.chemical_compound
Liver disease
0302 clinical medicine
Diabetes mellitus
Animals
Medicine
Hydrogen Sulfide
Pharmacology
Gasotransmitters
business.industry
Lipid metabolism
Metabolism
Lipid Metabolism
medicine.disease
Lipids
3. Good health
Metabolic pathway
030104 developmental biology
Liver
chemistry
Hepatic lipid
Knockout animal
business
030217 neurology & neurosurgery
Themed Section: Review Article
Subjects
Details
- ISSN :
- 14765381 and 00071188
- Volume :
- 177
- Database :
- OpenAIRE
- Journal :
- British Journal of Pharmacology
- Accession number :
- edsair.doi.dedup.....bba71d751c492c50392b67d3640f14f5