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Clinical profile and outcome of refractory convulsive status epilepticus in older children from a developing country
- Source :
- Seizure. 36:31-35
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Purpose The current study evaluates the etiology, clinical course and outcome of refractory convulsive status epilepticus (CSE) in older children. Methods Retrospective analysis of data of 73 children with CSE, aged ≥2 and ≤12 years was performed. Odds ratios were calculated between variables for clinical course and outcome. Mortality of the group was analyzed using survival analysis. Results Thirty three (45.2%) children progressed to refractory status epilepticus (RSE). The most common etiology for CSE was acute symptomatic in 44 (60.3%) of which 37 had presumed CNS infections. The odds of progressing to RSE were higher in children with acute symptomatic etiology (OR 2.62; CI – 95%; 0.99–7.14; p =0.041). Progression to RSE increased the chances of severe sepsis by six times (OR 6.08; CI – 95%; 1.19–31.02; p =0.036) and acidosis by nearly 15 times (OR 14.77; CI – 95%; 1.19–31.02; p =0.020). Overall mortality was 13.7%, higher in RSE (21.2% vs.7.5%). Amongst the 63 surviving children followed for 1 year from discharge, progression to RSE increased the odds of disability by seven times (OR 7.08; CI 29.31; p =0.004). Conclusion Acute symptomatic etiology was the commonest cause of CSE among older children from developing country and increased the odds of progressing to RSE. RSE was significantly associated with disability at 1 year from discharge.
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
Time Factors
Prednisolone
Clinical Neurology
Glasgow Outcome Scale
India
Developing country
Status epilepticus
Odds
03 medical and health sciences
Epilepsy
Status Epilepticus
0302 clinical medicine
Refractory
Humans
Medicine
030212 general & internal medicine
Child
Survival analysis
Retrospective Studies
business.industry
Electroencephalography
General Medicine
Odds ratio
medicine.disease
Survival Analysis
Treatment Outcome
Neurology
Child, Preschool
Etiology
Anticonvulsants
Female
Neurology (clinical)
medicine.symptom
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 10591311
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Seizure
- Accession number :
- edsair.doi.dedup.....bbb16a657f2092539f0857cd80640474